98%
921
2 minutes
20
Brachymetacarpia is the term for the shortening of the digit as a result of the metacarpal shortening. Isolated idiopathic brachymetacarpia is rarely reported in African countries, and its incidence is still unknown in the literature compared to brachymetatarsia, which is extensively reported. We report an uncommon case of a 26-year-old male patient who presented with short, symmetrical ring fingers without an associated medical condition. Clinical examination revealed signs in keeping with brachymetacarpia, while plain radiographs showed a metacarpal sign. Non-operative treatment was given for bilateral brachymetacarpia.
Download full-text PDF |
Source |
---|---|
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12245643 | PMC |
http://dx.doi.org/10.11604/pamj.2025.50.108.41420 | DOI Listing |
Cell Death Differ
September 2025
Graduate Institute of Physiology, College of Biomedical Sciences, National Defense Medical University, Taipei, Taiwan, Republic of China.
Peroxisome proliferator-activated receptor alpha (PPARα) is a crucial transcriptional factor that regulates fatty acid β-oxidation and ketogenesis in response to fasting. However, the mechanisms underlying PPARα function remain unclear. This study identified a novel PPARα-binding protein-RING finger protein 128 (RNF128)-that facilitates PPARα polyubiquitination, resulting in the degradation and suppression of PPARα function during fasting.
View Article and Find Full Text PDFChest
September 2025
Division of Pulmonology, Geneva University Hospitals, Hôpital de La Tour, Meyrin, Geneva, and Faculty of Medicine, Geneva, Switzerland. Electronic address:
Background: Nocturnal SpO monitoring is recommended for detecting residual sleep-disordered breathing (SDB), including nocturnal hypoventilation, in patients treated by non-invasive ventilation (NIV) or continuous positive airway pressure (CPAP). It is a general assumption that different pulse oximetry devices will provide similar results. This may, however, not be correct.
View Article and Find Full Text PDFFront Biosci (Landmark Ed)
August 2025
Department of Neurology, The First Affiliated Hospital, Fujian Medical University, 350005 Fuzhou, Fujian, China.
Background: Glioblastoma (GBM) is an extremely aggressive brain tumor, marked by restricted therapeutic possibilities and a generally unfavorable prognosis. GBM's complexity and heterogeneity necessitate comprehensive genetic and immunological profiling to enhance therapeutic strategies.
Methods: The study integrated The Cancer Genome Atlas (TCGA) and Integrative Epidemiology Unit Open Genome-Wide Association Studies (IEU OpenGWAS) data to identify genetic factors influencing GBM using expression quantitative trait loci (eQTL) and genome-wide association studies (GWAS).
Int Immunopharmacol
September 2025
Cancer Center and Center of Translational Medicine, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou 121001, China. Electronic address:
Ring finger protein 180 (RNF180) is an E3 ubiquitin-protein ligase that promotes polyubiquitination and degradation. We analyzed the roles and molecular mechanisms of RNF180 during the tumorigenesis and progression of colorectal cancer (CRC) through bioinformatics analysis, in vivo and vitro experiments. RNF180 overexpression was observed in CRC, and positively associated with T, N and TNM staging or differentiation.
View Article and Find Full Text PDFInt Immunopharmacol
September 2025
Department of Orthopaedics, Renmin Hospital of Wuhan University, Hubei Province, Wuhan 430060, China. Electronic address:
Background: Ring finger protein 207 (RNF207) is an E3 ubiquitin ligase that regulates the stability and activity of target proteins via ubiquitination and non-proteolytic mechanisms. However, its role in osteosarcoma pathogenesis and association with patient prognosis remain poorly understood.
Methods: We integrated bioinformatics analyses of public databases with assayal validation in osteosarcoma cell lines and clinical tissue samples to assess RNF207 expression and its prognostic significance.