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In this report, we describe the case of a newborn with a rare neonatal infection caused by Citrobacter koseri, which followed a fulminant course. Unfortunately, despite prompt initiation of the sepsis treatment protocol by the health care team, the newborn developed significant complications that affected the central nervous system. As a result, palliative care was instituted, and brain death was declared on the 12th day of life, 6 days after the onset of the first symptoms of the infection. We discuss the epidemiology of C. koseri infection; the therapeutic management of sepsis, including the role of the nurse; and the ethical considerations involved in clinical decision-making. We present this case to encourage reflection on strategies to detect subtle signs of infection and respond early in a critical effort to prevent severe complications.
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http://dx.doi.org/10.1016/j.jogn.2025.06.003 | DOI Listing |
Rev Esp Quimioter
August 2025
Instituto de Investigación Biosanitaria de Granada, Granada, España.
Elife
August 2025
Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, United States.
Previously, we showed Enterobacteriaceae use chemotaxis and the chemoreceptor Tsr for attraction to blood serum (Glenn et al., 2024). Here, we investigated the complementary role of Tsr in mediating chemorepulsion, a behaviour by which motile bacteria avoid deleterious compounds to locate permissive niches.
View Article and Find Full Text PDFLancet Microbe
July 2025
Laboratory Medicine Center, Department of Clinical Laboratory, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou, Zhejiang, China. Electronic address:
Background: Carbapenemase-producing Citrobacter (CPC) species have recently been recognised as emerging pathogens associated with nosocomial infections in humans. The increased rate of Citrobacter freundii infections is a public health concern and there is a paucity of genomic data regarding its global transmission dynamics. We aimed to characterise the genetic features of CPC species, and their associated carbapenemase-encoding plasmids, obtained from hospitalised patients in China and from publicly available global data, with a particular focus on high-risk clones.
View Article and Find Full Text PDFJ Obstet Gynecol Neonatal Nurs
July 2025
In this report, we describe the case of a newborn with a rare neonatal infection caused by Citrobacter koseri, which followed a fulminant course. Unfortunately, despite prompt initiation of the sepsis treatment protocol by the health care team, the newborn developed significant complications that affected the central nervous system. As a result, palliative care was instituted, and brain death was declared on the 12th day of life, 6 days after the onset of the first symptoms of the infection.
View Article and Find Full Text PDFBioinformation
April 2025
Department of Microbiology, Central Laboratory, Institute of Medical Sciences and SUM Hospital -III, SOA (Deemed to be University), Sitalapalli, Narendrapur - 760007, Ganjam, Odisha, India.
The cost-effective herbal disinfectant formulations from indigenously available plants with their potential antimicrobial activity against hospital-derived microbial flora are of interest. Hence, a total of six herbal disinfectant formulations were prepared with indigenously available plants and tested for the antimicrobial activity using a standard protocol. The results show that isolated from the Ophthalmology ward showed the highest sensitivity to herbal disinfectant and the inhibition zone identified was 35mm higher than standard tested antibiotics.
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