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| http://dx.doi.org/10.1016/j.ijgc.2025.101985 | DOI Listing |
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Article Synopsis
- For years, the importance of changes in the uterine extracellular matrix (ECM) during dog pregnancy was overlooked, but new research shows that free-floating embryos influence ECM composition.
- The study revealed that specific genes related to structural functions and cell communication are affected by the presence of these embryos, which may facilitate trophoblast invasion and uterine function.
- Results indicate that while early pregnancy shows minor ECM modifications, significant remodeling happens post-implantation to prepare the uterus for fetal development and membrane release, highlighting the dog's potential as a model for studying similar processes in other species.