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Micro-controlled lower limb prosthetic devices typically employ onboard sensors on the amputated side of the user's body to generate control patterns. However, balanced ambulation in a healthy subject requires synchronized neural control to facilitate appropriate positioning and orientation of both limbs. Building upon this idea, this study introduces a control architecture that utilizes information acquired from both limbs using only two inertial measurement units (one placed on the left shank, and one placed on the right thigh) to generate the control commands for a transtibial prosthesis prototype clamped to a table-top. Multiple trials were performed with a healthy subject walking on level ground at different speeds and undertaking an obstacle avoidance task. The results of the experiments suggest that incorporating data from each side provides comprehensive information about the limb's positions and orientations, thereby enabling a controller that can handle actuation timing and assist in precise prosthesis control through an understanding of the user's gait states.
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http://dx.doi.org/10.1109/ICORR66766.2025.11063099 | DOI Listing |
Nano Lett
September 2025
Depto. Polimeros y Materiales Avanzados: Fisica, Quimica y Tecnologia, Universidad del País Vasco, UPV/EHU, 20018 San Sebastian, Spain.
We demonstrate a novel approach to controlling and stabilizing magnetic skyrmions in ultrathin multilayer nanostructures through spatially engineered magnetostatic fields generated by ferromagnetic nanorings. Using analytical modeling and micromagnetic simulations, we show that the stray fields from a Co/Pd ferromagnetic ring with out-of-plane magnetic anisotropy significantly enhance the Néel-type skyrmion stability in an Ir/Co/Pt nanodot, even stabilizing the skyrmion in the absence of Dzyaloshinskii-Moriya interactions. We demonstrate precise control over the skyrmion size and stability.
View Article and Find Full Text PDFArterioscler Thromb Vasc Biol
September 2025
Vascular Biology Program, Boston Children's Hospital and Harvard Medical School, MA (K. Cui, B.Z., B.W., S.E.-B., A.V., H.C.).
Background: Atherosclerosis is a chronic inflammatory disease characterized by the accumulation of lipid-laden foam cells and plaques within the arterial wall. Dysfunctional vascular smooth muscle cells (VSMCs), fibroblasts, endothelial cells, and macrophages contribute to disease progression. Here, we report that macrophage-specific expression of epsins, highly conserved endocytic adaptor proteins involved in clathrin-mediated endocytosis, accelerates atherosclerosis in Western diet-fed mice.
View Article and Find Full Text PDFFuture Oncol
September 2025
Department of General Surgery, Institute of General Surgery, Northern Jiangsu People's Hospital Affiliated to Yangzhou University, Yangzhou University, Yangzhou, China.
Immune checkpoint therapy has demonstrated significant potential in the treatment of various solid tumors. Among these, tumor-induced immunosuppression mediated by programmed cell death protein 1 (PD-1) represents a critical checkpoint. PD-1/programmed death-ligand 1 (PD-L1) inhibitors have been proven to exhibit substantial efficacy in solid tumors such as melanoma and bladder cancer.
View Article and Find Full Text PDFDiabetes Technol Ther
September 2025
3rd Department of Internal Medicine, General University Hospital, Prague, Czech Republic.
This study was designed to investigate the switch between the open-source automated insulin delivery (OS-AID) system AndroidAPS (AAPS) and commercially available AID systems Control-IQ (CIQ) and MiniMed 780G (780G) conducted in a new extended follow-up study. In this prospective open-label single-arm clinical trial, 41 adults with type 1 diabetes (age 35 ± 11 years, glycated hemoglobin [HbA1c] 6.4 ± 2.
View Article and Find Full Text PDFF1000Res
September 2025
School of Management, University of Khartoum, Khartoum, Khartoum, Sudan.
Background: At the 2020 UN General Assembly, China pledged to peak carbon emissions before 2030 and achieve carbon neutrality by 2060. However, the traditional social development model has led to increasing carbon emissions annually, highlighting the need to resolve the contradiction between development and carbon reduction. This study examines the relationship between carbon emissions, economy, population, and energy consumption in a specific region to support carbon peak and neutrality goals.
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