98%
921
2 minutes
20
We report an efficient one-pot, three-component synthesis of ferrocenyl-substituted allylamine derivatives with α-(hydroxy) alkyl ferrocenes, aldehydes and amines. The advantages of this method are its catalyst-free nature, broad substrate scope, operational simplicity and mild reaction conditions. The origin of this one-pot synthesis of ferrocenyl-substituted allylamine derivatives was explored through density functional theory calculations.
Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.1039/d5ob00652j | DOI Listing |
Molecules
June 2025
Department of Chemistry, Institute of Pure and Applied Sciences, University of Tsukuba, 1-1-1 Tennoudai, Tsukuba 305-8571, Ibaraki, Japan.
Heavier element analogues of a ketone, a C=O double-bond compound, have been fascinating compounds from the viewpoint of main-group element chemistry because of their unique structural features and reactivity as compared with those of a ketone, which plays an important role in organic chemistry. We will report here the synthesis of diorgano-stannanethione and stannaneselone featuring tin-chalcogen double bonds, which are the heavy-element analogues of a ketone. The newly obtained stannaneselone has been structurally characterized by spectroscopic analyses and single-crystal X-ray diffraction (SC-XRD) analysis, showing the short Sn-Se bond length featuring π-bond character.
View Article and Find Full Text PDFOrg Biomol Chem
July 2025
School of Pharmacy, Ningxia Medical University, 750004 Yinchuan, China.
We report an efficient one-pot, three-component synthesis of ferrocenyl-substituted allylamine derivatives with α-(hydroxy) alkyl ferrocenes, aldehydes and amines. The advantages of this method are its catalyst-free nature, broad substrate scope, operational simplicity and mild reaction conditions. The origin of this one-pot synthesis of ferrocenyl-substituted allylamine derivatives was explored through density functional theory calculations.
View Article and Find Full Text PDFDalton Trans
April 2025
Department of Inorganic Chemistry, Faculty of Science, Charles University, Hlavova 2030, 128 40 Prague, Czech Republic.
Triazolylidenes derived from readily accessible triazoles are useful ligands for coordination chemistry and catalysis. This work describes the synthesis of Group 11 metal complexes of new ferrocenyl-substituted triazolylidene ligands in which the ferrocene and triazolylidene moieties are separated by a carbonyl linker. In particular, complexes of types [MCl(FcC(O){CN(Mes)NN(Me)}-κ)] (M = Cu or Au; Fc = ferrocenyl) and [M(FcC(O){CN(Mes)NN(Me)}-κ)][BF] (M = Cu, Ag, or Au) were prepared from FcC(O)CCH and characterised by spectroscopic methods, X-ray diffraction analysis and cyclic voltammetry.
View Article and Find Full Text PDFDalton Trans
April 2025
Department of Chemistry, Indian Institute of Technology Indore, Indore-453552, India.
A set of ferrocenyl functionalized phenothiazine derivatives Fc1-4 were designed and synthesized Pd-catalyzed Buchwald-Hartwig and Suzuki cross-coupling reactions. Phenothiazine was used as a central donor and ferrocenyl as a terminal donor unit. Herein we examine the impact of variation of substituents at the -position of phenothiazine, including H, phenyl, phenyl-linked ferrocenyl, and biphenyl-linked ferrocenyl units on the photophysical, electrochemical, and thermal behaviors.
View Article and Find Full Text PDFACS Omega
December 2024
Tianjin Key Laboratory of Therapeutic Substance of Traditional Chinese Medicine, School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, P. R. China.
A panel of ferrocenyl-substituted curcumin derivatives has been designed and synthesized as protein tyrosine phosphatase proto-oncogene SHP-2 inhibitors. Antiproliferative activities of the synthesized compounds were tested against colorectal cancer cell lines (including RKO, SW480, and CT26). Compound showed excellent activities against the tested cell lines with IC values of 5.
View Article and Find Full Text PDF