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Rationale: Cervical spondylotic myelopathy (CSM) is the most prevalent spinal cord impairment among adults, primarily due to age-related degenerative changes. Although surgical interventions are commonly recommended for severe cases, the optimal timing and procedural complexities remain controversial. Evidence supporting the efficacy of Korean medicine (KM) as a treatment alternative for CSM is currently limited.
Patient Concerns: This report details 2 cases involving middle-aged Korean patients presenting with significant neck pain, upper extremity numbness, and muscle weakness. Case 1 involved a 50-year-old male (172 cm, 80 kg) experiencing left arm numbness, muscle weakness, and neck pain persisting for 3 months. Case 2 involved a 51-year-old male (182 cm, 85 kg) with persistent right arm and neck symptoms for 12 months.
Diagnoses: Both patients were diagnosed with cervical compressive myelopathy associated with herniated intervertebral disc - Case 1 at cervical levels C4-C6 and Case 2 at cervical levels C6-C7.
Interventions: Patients received integrated KM treatments, including acupuncture, pharmacopuncture (particularly Shinbaro pharmacopuncture), herbal medicine, and Chuna manual therapy.
Outcomes: Both patients exhibited significant improvements in neck and arm pain, assessed via numeric rating scales. Additionally, manual muscle testing indicated notable enhancements in triceps brachii muscle strength.
Lessons: The reported cases highlight KM treatment as a promising nonsurgical alternative for managing mild to moderate CSM, particularly in patients reluctant or unsuitable for surgery. KM treatments showed efficacy in improving pain, numbness, and muscular strength. Further rigorous studies are necessary to evaluate and confirm the broader applicability and effectiveness of KM approaches for CSM management.
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http://dx.doi.org/10.1097/MD.0000000000043085 | DOI Listing |
BMC Emerg Med
September 2025
Department of Neurology and Clinical Neuroscience, Faculty of Medicine and Medical Center, University of Freiburg, Freiburg, Germany.
Background: Identifying suspected anterior circulation large-vessel occlusion (aLVO) strokes during emergency calls could enhance dispatch efficiency, particularly in rural areas. However, data on emergency medical dispatchers' (EMDs) ability to recognize aLVO symptoms remain limited. This simulation study aimed to evaluate the feasibility of identifying side-specific arm paresis, side-specific conjugate eye deviation (CED), and aphasia during emergency calls by instructing layperson callers to perform brief, standardized examination steps.
View Article and Find Full Text PDFMethods Cell Biol
September 2025
The HIT Center for Life Sciences, Harbin Institute of Technology, Harbin, P.R. China; Medical and Health Research Institute, Zhengzhou Research Institute of HIT, Zhengzhou, HA, P.R. China. Electronic address:
Amyotrophic lateral sclerosis (ALS) is a severe neurodegenerative disorder characterized by progressive degeneration of motor neurons, leading to muscle weakness, paralysis, and death. While there is a plethora of studies focusing on many aspects of ALS, the pathogenesis of this disease is not well understood, and effective treatments are scarce. Drosophila melanogaster is a powerful model organism for studying ALS due to its genetic tractability and its evolutionarily conserved cellular and molecular processes which are also shared between the fly and human.
View Article and Find Full Text PDFJ Neurol Neurosurg Psychiatry
September 2025
Department of Neurosciences and Behavioural Sciences, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, São Paulo, Brazil
Background: Biallelic variants lead to autosomal recessive Charcot-Marie-Tooth type 4C (CMT4C) which is typically demyelinating and associated with early-onset spinal deformities. Electrophysiology typically reveals a non-uniform conduction velocity (CV) slowing, a pattern traditionally linked to inflammatory neuropathies, potentially leading to diagnostic misinterpretation.
Objective And Methods: Clinical and neurophysiological data from 19 patients belonging to 16 unrelated families with confirmed CMT4C were retrospectively collected across six neuromuscular reference centres in Brazil.
Respir Care
September 2025
Dr. Thomasian and Prof. Wunsch are affiliated with Department of Anesthesiology, Weill Cornell Medicine, New York, New York, USA.
Negative-pressure ventilation (NPV) is a form of noninvasive respiratory support in which an external subatmospheric pressure is applied to the thorax to facilitate lung expansion. Although largely supplanted by positive-pressure ventilation (PPV) in modern-day practice, NPV has garnered renewed interest as a potential noninvasive adjunct or alternative to PPV. Appropriate patient selection would be key, particularly in the ICU setting, where NPV is generally contraindicated in patients with severe upper airway obstruction, high oxygenation requirements, or absent airway reflexes.
View Article and Find Full Text PDFRespir Physiol Neurobiol
September 2025
Department of Pediatrics, School of Medicine, Duke University.
Pompe disease is an autosomal recessive neuromuscular disorder characterized by a deficiency of acid α-glucosidase (GAA), an enzyme responsible for lysosomal glycogen degradation in all cells. Respiratory distress is a common symptom among patients with Pompe disease resulting from weakness of primary respiratory neuromuscular units of the diaphragm and genioglossus and the motor neurons which innervate them. The only FDA approved treatment is enzyme replacement therapy (ERT) of recombinant human GAA (rhGAA) which slows the decline of motor function and extends life expectancy.
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