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http://dx.doi.org/10.3928/23258160-20250619-01 | DOI Listing |
Ophthalmic Surg Lasers Imaging Retina
August 2025
Vitreo Retina and Uvea Service, Dr. Shroff’s Charity Eye Hospital, New Delhi, India
JCO Precis Oncol
July 2025
Department of Oncology, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY.
Purpose: CNS involvement in North American adult T-cell leukemia/lymphoma (NA-ATLL) remains poorly understood. This study examined the CNS involvement in patients with ATLL treated at a tertiary hospital in New York City.
Methods: CNS involvement was defined by positive cerebrospinal fluid (CSF) cytology, flow cytometry, positive CNS imaging, or neurological examination findings.
Ophthalmic Surg Lasers Imaging Retina
July 2025
Ophthalmic Surg Lasers Imaging Retina
June 2025
J Clin Oncol
August 2025
Wilmot Cancer Institute, University of Rochester Medical Center, Rochester, NY.
Purpose: Pirtobrutinib, a noncovalent, Bruton tyrosine kinase inhibitor (BTKi), has shown clinical efficacy and a favorable safety profile. BRUIN CLL-321 was an open-label, randomized phase III study conducted exclusively in patients with R/R chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma (SLL) previously treated with cBTKi, and compared pirtobrutinib with investigator's choice (IC) of idelalisib/rituximab (IdelaR) or bendamustine/rituximab (BR).
Methods: Patients were randomly assigned 1:1 to receive pirtobrutinib (200 mg once daily) or IC of IdelaR or BR, and were stratified by previous use of venetoclax and del(17p).