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Article Abstract
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12240459 | PMC |
| http://dx.doi.org/10.1097/ALN.0000000000005545 | DOI Listing |
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Phagocytosis is mediated mainly by immune cells, such as macrophages, monocytes and neutrophils, that clear large pathogens including bacteria. The small GTP-binding protein Rab5 is crucial for both clathrin-dependent endocytosis and phagocytosis, but the role and mechanism of Rab5 activation during phagocytosis are poorly understood. Here we report that nitric oxide (NO), a novel regulator of Rab5, regulates phagocytosis through S-nitrosylation of Rab5.
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