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Purpose: Physiological knee kinematics typically exhibit a medial pivot (MP) pattern and femoral rollback during flexion. There is a significant gap in the literature pertaining to the evaluation of kinematic patterns following total knee arthroplasty (TKA). The aim of this study was to evaluate the proportion of patients achieving a MP kinematic pattern following robotic-arm-assisted TKA using functional positioning.
Methods: Sixty consecutive patients who underwent primary robotic-assisted TKA employing functional positioning were investigated. Following final positioning, sensor-embedded tibial trials were used to assess the kinematic pattern. Two senior fellowship-trained surgeons documented the kinematic tracking of the tibiofemoral articulation and centre of load on the sensor display monitor. The differential load pressure was captured intraoperatively at 10°, 45° and 90° to substantiate the kinematic pattern. Significance was for -value < 0.05.
Results: A MP kinematic pattern was observed in 29 patients (48%). These patients exhibited a median medial load of 21.0 lbf at 10°, 15 lbf at 45° and 13 lbf at 90°, while the median lateral load was 13 lbf at 10°, 8 lbf at 45° and 6 lbf at 90°. The patients with MP kinematics were associated with significantly greater medial measured loads at 10° flexion (21 vs. 18 lbf; < 0.001) and with lower measured loads in the lateral compartment at 10° (13 vs. 15 lbf; = 0.011), 45° (8 vs. 13 lbf; = 0.011) and 90° of flexion (6 vs. 10 lbf; < 0.001). Mean differential load pressure between the compartments was <15 lbf at 10°, 45° and 90° in both groups.
Conclusion: In our cohort, using robotic arm assistance with functional positioning, we observed a MP kinematic pattern in approximately 50% of the cases. Further longer-term studies are warranted to evaluate the impact of the kinematic pattern on clinical and patient-reported outcomes.
Level Of Evidence: Level III, retrospective cohort study.
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http://dx.doi.org/10.1002/jeo2.70343 | DOI Listing |
Philos Trans A Math Phys Eng Sci
September 2025
Department of Biology, Dalhousie University, Halifax, Nova Scotia, Canada.
Flagellates, unicellular organisms equipped with one or a few flagella, are phylogenetically and functionally hugely diverse. Yet, most studies have focused on a few model organisms and on the role of the flagellum in propulsion, ignoring the fundamental role of the flagellum in foraging. The number and position of flagella vary between species; the flagella may be naked or equipped with vanes or hairs; the kinematics and wave patterns vary and may be planar or three-dimensional; and the flagellum may extend from the surface of the cell or lie within a groove on the cell surface.
View Article and Find Full Text PDFBMJ Open
September 2025
Department of Rehabilitation, Shengjing Hospital of China Medical University, Shenyang, Liaoning, Chinax
Objectives: This study evaluated the effects of proximal core training on biomechanical risk factors and strength parameters in individuals at high risk of anterior cruciate ligament (ACL) injury (specifically: those exhibiting pathological movement patterns, neuromuscular deficits or biomechanical risk factors) and compared direct versus indirect interventions. We hypothesised that targeted training enhances dynamic knee stabilisation and hip control during high-risk manoeuvres, with direct approaches providing superior biomechanical benefits through neuromuscular control optimisation.
Design: Systematic review and meta-analysis using the Grading of Recommendation, Assessment, Development and Evaluation (GRADE) approach.
Sci Adv
September 2025
Movement Disorder and Neuromodulation Unit, Department of Neurology, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
Subthalamic deep brain stimulation (STN-DBS) provides unprecedented spatiotemporal precision for the treatment of Parkinson's disease (PD), allowing for direct real-time state-specific adjustments. Inspired by findings from optogenetic stimulation in mice, we hypothesized that STN-DBS can mimic dopaminergic reinforcement of ongoing movement kinematics during stimulation. To investigate this hypothesis, we delivered DBS bursts during particularly fast and slow movements in 24 patients with PD.
View Article and Find Full Text PDFSports Med Open
September 2025
Division of Physiological Sciences, Department of Human Biology, Faculty of Health Sciences, University of Cape Town, Newlands, Cape Town, 7725, South Africa.
Background: In tackle-collision sports, the tackle has the highest incidence, severity, and burden of injury. Head injuries and concussions during the tackle are a major concern within tackle-collision sports. To reduce concussion and head impact risk, evaluating optimal tackle techniques to inform tackle-related prevention strategies has been recommended.
View Article and Find Full Text PDFNEJM AI
September 2025
Department of Bioengineering, Stanford University, Stanford, CA.
Background: Assessing human movement is essential for diagnosing and monitoring movement-related conditions like neuromuscular disorders. Timed function tests (TFTs) are among the most widespread types of assessments due to their speed and simplicity, but they cannot capture disease-specific movement patterns. Conversely, biomechanical analysis can produce sensitive disease-specific biomarkers, but it is traditionally confined to laboratory settings.
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