Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Background: Cerebellar dysfunction is strongly implicated in both cognitive impairments and psychosis, and the cognitive dysmetria hypothesis posits cognition as the intermediary in the pathway from cerebellar dysfunction to psychopathology. However, the nuanced cerebellum-behavior relationships in psychosis remain unclear. Establishing such a link is crucial to understand cerebellar mechanisms and to identify treatment targets for cognitive deficits in patients.
Methods: We studied 100 patients with early psychosis from the Human Connectome Project for Early Psychosis study. Connectome-based predictive modeling was conducted to probe cognitive functions most strongly predicted by cerebellar connectivity. Mediation analysis was performed to test for a possible mediating role of cognition between cerebellar connectivity and symptoms. To further support the causality of the findings, we also recruited 16 patients with psychosis for a 2-week randomized, sham-controlled cerebellar transcranial magnetic stimulation (TMS) trial.
Results: Cerebellar connectivity significantly predicted 3 cognitive functions, namely verbal ability, working memory, and cognitive flexibility. Verbal ability fully mediated the relationship between cerebellar connectivity and negative symptoms, in particular alogia. While each cognitive function was predicted by a distinct cerebellar connectivity pattern, the left crus I/II appeared to be a common area with connectivity that consistently predicted all 3 functions. Stimulating this region via TMS was associated with significantly improved cognitive composite score and medium-to-large effects on scores for memory, verbal, and executive functions.
Conclusions: These findings suggest a potential causal pathway from cerebellar connectivity to domain-specific cognitive deficits and psychopathology in schizophrenia. They also point to the cerebellum as a potential target for the treatment of cognitive dysfunction in psychotic disorders.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12351477 | PMC |
| http://dx.doi.org/10.1016/j.biopsych.2025.06.023 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Improvements in Resting-State Functional Connectivity of the Cerebellum after Transcranial Photobiomodulation in Adults with a History of Repetitive Head Acceleration Events.
Photobiomodul Photomed Laser Surg
September 2025
Department of Neurology, University of Utah School of Medicine, Salt Lake City, Utah, USA.
The current study sought to explore the impact of a novel noninvasive treatment called transcranial photobiomodulation (PBM) on resting-state functional connectivity (rsFC) of the cerebellum in individuals with a history of repetitive head acceleration events (RHAEs). RHAEs are associated with cumulative neurological compromise, including chronic alterations in rsFC; however, few treatments have been investigated to mitigate these effects. A recent study by our team demonstrated that PBM treatment led to improvements in measures of balance and motor function in adults with RHAE exposure.
View Article and Find Full Text PDFFaster rhythmic auditory cueing induced less severe movement abnormalities in people with subclinical psychosis.
Ann N Y Acad Sci
September 2025
Clinical Medicine and Advanced Applied Research Department, Point Robotics Medtech Incorporation, Taipei, Taiwan.
People with psychotic experiences (PE) have movement abnormalities, including slow movements and uncontrolled movements, which are indicative of transition to psychotic disorders. Rhythmic auditory cueing (RAC) has been indicated to be a promising therapeutic technique for movement abnormalities in people in the psychosis continuum; however, small sample size limited the strength of that conclusion. The aims of our study were to increase the sample size, adopt a repeated measures design, and examine if faster RAC induced faster movements and less uncontrolled movements in both hands in people with PE.
View Article and Find Full Text PDFDistinct cerebellar networks underpin clinical improvement in adolescent Tourette disorder.
Brain
September 2025
Sorbonne University, Inserm U1127, CNRS UMR7225, UM75, Paris Brain Institute, Movement Investigation and Therapeutics Team, 75013 Paris, France.
Adolescence is frequently called the second brain maturation period. In Tourette disorder (TD), the clinical trajectory of tics and associated psychiatric co-morbidities vary significantly across individuals during the transition from adolescents to adulthood. In this study, we aimed to identify patterns of resting-state functional connectivity that differentiate adolescents with TD from their neurotypical peers, and to monitor symptom-specific functional changes over time.
View Article and Find Full Text PDFFractional Amplitude of Low-Frequency Fluctuations and Regional Homogeneity Analyses Revealed Altered Local Spontaneous Neural Activities in Ankylosing Spondylitis.
J Pain Res
September 2025
Radiology Department, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, People's Republic of China.
Purpose: Previous studies have revealed alterations of the functional connectivity of the brain networks in ankylosing spondylitis (AS). Fractional amplitude of low-frequency fluctuations (fALFF) and regional homogeneity (ReHo) are both voxel-based functional metrics capable of estimating local spontaneous neural activities. This study aimed to investigate the local spontaneous neural activities in AS patients by utilizing the analytical approaches of fALFF and ReHo.
View Article and Find Full Text PDFIndividualised connectomic-guided radiosurgical thalamotomy for chronic pain.
Br J Neurosurg
September 2025
Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, UK.
Introduction: Radiosurgery targeting the thalamus has long been used to treat refractory pain, with medial thalamotomy as a key approach. Traditionally, targeting relied on indirect methods based on anatomical atlases, which do not account for individual variations in brain connectivity. Recent advances in connectomic-guided stereotactic radiosurgery have improved precision in the treatment of movement disorders, but their application to pain management remains underexplored.
View Article and Find Full Text PDF