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Ventricular septal defects (VSDs), the most common of congenital heart defects, vary widely in anatomy and size. Surgical treatment of very large VSDs can be challenging because no clear recommendations exist about which defects can undergo biventricular repair with septation and which should instead be palliated. Although Fontan circulation is known to be associated with long-term morbidity, information is limited about how ventricular septation of large VSDs affects cardiac function. This case series describes the successful ventricular septation of 3 patients with large VSDs and the lessons we learned in treating them.
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http://dx.doi.org/10.1016/j.jaccas.2025.103797 | DOI Listing |
JACC Case Rep
July 2025
Division of Cardiovascular Surgery, Labatt Family Heart Centre, The Hospital for Sick Children, Toronto, Canada.
Background: We present 2 cases of traumatic ventricular septal defects (VSDs), both caused by horse kick injuries. Given this rare but critical condition, we decided to share our experiences and the lessons learned managing these cases.
Case Summary: The first patient, a 12-year-old girl, was trampled by a horse, sustained a traumatic apical ventricular septal defect with pseudoaneurysm, was stabilized first, and underwent surgical closure 19 days after the injury.
Catheter Cardiovasc Interv
July 2025
Department of Pediatric Cardiology, Dr. Siyami Ersek Training and Research Hospital for Cardiology and Cardiovascular Surgery, İstanbul, Turkey.
Background And Aims: Perventricular device closure of muscular VSD in small infants is a less invasive option than surgical closure under cardiopulmonary bypass and offers better outcomes than palliative pulmonary artery banding. However, the specific risk factors that could affect procedural success and optimal outcomes have not been comprehensively examined in prior studies. The aim of this study is to analyze the risk factors for procedural failure and nonoptimal outcome in perventricular device closure of muscular VSD.
View Article and Find Full Text PDFJ Perinat Med
July 2025
Department of Gynecology, Fertility, and Obstetrics, Center of Fetal Medicine and Pregnancy, 53146 Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark.
Objectives: To compare 2nd-trimester cardiac and fetal biometries, 1st-trimester biomarkers, and obstetric outcome between children with an isolated ventricular septum defect (iVSD) and healthy children in a large cohort of children with neonatal echocardiography.
Methods: The Copenhagen Baby Heart Study offered all neonates born in Copenhagen an echocardiography within the 60 days of life between 2016 and 2018. The mothers were recruited at the 2nd-trimester scan (18+0 to 22+6).
Catheter Cardiovasc Interv
September 2025
Department of Ultrasound, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China.
Background: To reduce complications associated with metal occluders, bioabsorbable occluders have been implanted for perimembranous ventricular septal defects (VSDs) via transthoracic approach. This study investigates the feasibility of echocardiography-guided percutaneous closure of perimembranous VSDs in children using bioabsorbable occluders, along with its 1-year follow-up outcomes.
Aims: To evaluate the feasibility and 1-year outcomes of echocardiography-guided percutaneous closure of perimembranous VSDs using bioabsorbable occluders in children.
bioRxiv
June 2025
Department of Chemistry, University of Massachusetts, Amherst, MA 01003, USA.
Voltage-dependence gating of ion channels underlies numerous physiological and pathophysiological processes, and disruption of normal voltage gating is the cause of many channelopathies. Here, long timescale atomistic simulations were performed to directly probe voltage-induced gating transitions of the big potassium (BK) channels, where the voltage sensor domain (VSD) movement has been suggested to be distinct from that of canonical Kv channels but remains poorly understood. Using a Core-MT construct without the gating ring, multiple voltage activation transitions were observed at 750 mV, allowing detailed analysis of the activated state of BK VSD and key mechanistic features.
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