[Gene Mutation Characteristics, Prognosis and Survival Analysis of Patients with Acute Myeloid Leukemia].

Objective: To analyze the gene mutation characteristics and survival time of patients with newly diagnosed acute myeloid leukemia (AML) based on next-generation sequencing(NGS) gene detection.

Methods: A retrospective analysis was conducted on the clinical data of 92 patients with AML (non APL) admitted to our hospital from January 2018 to May 2022. AML related genes tested were using NGS, the mutation characteristics and survival time of AML patients were analyzed.

Results: Among the 92 patients, 41 were males and 51 were females. A total of 38 types of gene mutations were detected. Six-two patients carried at least one gere mutation, while no gene mutations were detected in 30 patients. In the group with favourable prognosis ( =14), the frequencies of higher gene mutations were (21.43%, =3), (14.29%, =2). In the group with intermediate prognosis ( =64), the gene mutation frequencies from high to low were (18.75%, =12), (17.19%, =11), (12.50%, =8), (10.94%, =7). In the poor prognosis group ( =14), had higher gene mutation frequency than others(14.29 %, =2 ). Statistical analysis revealed that had a relative hotspot of mutations in the intermediate-risk group, and had a relative hotspot of mutations in the high-risk group ( < 0.05). The correlation analysis of genes with high mutation rates in different prognostic groups, such as , and , with prognosis found that was a factor affecting OS ( < 0.05), while no significant differences were observed for the others( >0.05).

Conclusion: The frequency of gene mutations is high in AML patients, 67.4% of the patients carried at least one gene mutation. The mutation frequency varies among different genes in patients with different karyotypes, and there are obvious dominant mutations. and can be used as factors for evaluating the prognosis of AML.