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We report the first case of human rabies in a child from Amazonas after 10 years without an outbreak. An 8-year-old girl was admitted to the local hospital because of headache, myalgia, diarrhea, fever, and vomiting during the previous 4 days. Meningoencephalitis was suspected, and empiric therapy with ceftriaxone and vancomycin was started. However, in the following 3 days, she also presented progressive lower extremities weakness, behavioral changes, photophobia, irritability, sialorrhea, and hallucinations. Thus, she was transferred to our hospital. Phenytoin, dexamethasone, mannitol, and acyclovir were started, and ceftriaxone was continued. Five days later, the mother recalled that the patient was bitten by a feral cat. Thus, human rabies immunoglobulin serum was administered immediately. However, 2 days later, the patient died. Post-mortem brain direct immunofluorescence study confirmed human rabies. Awareness campaigns can be lifesaving since more than 99% of deaths can be prevented if timely treatment is provided.
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http://dx.doi.org/10.1177/30502225251318115 | DOI Listing |
Brain
September 2025
State Key Laboratory of Bioactive Molecules and Druggability Assessment, Guangdong Basic Research Center of Excellence for Natural Bioactive Molecules and Discovery of Innovative Drugs, Guangdong Provincial Key Laboratory of Non-human Primate Research, Guangdong-Hong Kong-Macau Institute of CNS Rege
Abnormal accumulation of TAR DNA-binding protein-43 (TDP-43) is a hallmark of amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD). Small interfering RNAs (siRNAs) targeting TDP-43 offer potential therapeutic strategies for these diseases. However, efficient and safe delivery of siRNAs to the central nervous system (CNS) remains a critical challenge.
View Article and Find Full Text PDFPLoS Negl Trop Dis
September 2025
Institute of Immunology & Infection Research, University of Edinburgh, Ashworth Laboratories, Edinburgh, United Kingdom.
Background: Neglected tropical diseases (NTDs) are a group of 21 diseases affecting approximately 1.5 billion people globally. Significant progress has been made in their control: by March 2024, 50 countries had eliminated at least one NTD, with 13 of these countries eliminating at least two.
View Article and Find Full Text PDFFood Waterborne Parasitol
September 2025
Anses, Laboratory for Food Safety, Boulogne-sur-Mer, France.
Over the last two decades, the popularization of new eating habits and the increase in fish products demand led to a raising risk for consumers due to food-borne parasitic zoonoses. Species of Leidy, 1856 are cosmopolitan zoonotic digenetic trematodes. They are present, at the juvenile stage, in numerous freshwater fish.
View Article and Find Full Text PDFSci Rep
August 2025
Department of Clinical Pharmacy, School of Pharmacy, College of Medicine and Health Science, Bahir Dar University, Bahir Dar, Ethiopia.
Rabies is a dangerous viral neglected tropical disease and infects humans, causing big problems for health authorities in Ethiopia. Though PEP is available, still there is insufficient awareness, difficulties of accessing to healthcare and logistics issues still make it hard for some to properly follow the rabies vaccination schedule. The primary aim of this study is to measure how properly the anti-rabies vaccine is given and to determine which factors influence the schedule among patients in Addis Alem General Hospital, Bahir Dar.
View Article and Find Full Text PDFViruses
August 2025
Department of Microbiology, Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, Australia.
The rabies virus (RABV) phosphoprotein (P protein) has multiple functions, including acting as the essential non-catalytic cofactor of the viral polymerase (L protein) for genome replication and transcription; the principal viral antagonist of the interferon (IFN)-mediated innate immune response; and the chaperone for the viral nucleoprotein (N protein). Although P protein is known to undergo phosphorylation by cellular kinases, the location and functions of the phosphorylation sites remains poorly defined. Here, we report the identification by mass-spectrometry (MS) of residues of P protein that are modified by phosphorylation in mammalian cells, including several novel sites.
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