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Article Abstract
A Cu(I)-catalyzed [4 + 1] cycloaddition reaction between -quinone methides and terminal alkynes has been developed, demonstrating good compatibility with both stable and in situ generated -quinone methides. This methodology offers several significant advantages, including operational simplicity, wide substrate compatibility, and the ability to access synthetically useful 2,3-disubstituted benzofuran compounds in generally good to high yields (44 examples, up to 91% yield).
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