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Many fields in science and industry rely on the advances of nanofabrication processes. However, well-established techniques, such as electron beam lithography, might pose restrictions on dielectric materials due to surface charging effects. We propose using pulsed thermal scanning probe lithography to directly assemble high resolution patterns on insulating substrates. We applied this methodology to meet the requirements of fabricating all-dielectric metasurfaces. The pulsed thermal scanning probe lithography process, operating in standard room conditions, provided sub-10nm resolution for patterning on silica without the need of any additional conductive layers. Thus, the proposed technique improves material compatibility for nanofabrication and consequently enables the exploration of dielectric material properties across a wide range of devices.
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http://dx.doi.org/10.1038/s41598-025-07428-1 | DOI Listing |
Am J Chin Med
September 2025
Shanghai Frontiers Science Center of TCM Chemical Biology, Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
Astragaloside IV (ASIV), the main active component of the traditional Chinese medicine HuangQi, exhibits ameliorating effects on myocardial fibrosis through unclear mechanisms. To investigate the effects of ASIV on Endothelial-to-mesenchymal transition (EndMT) in myocardial fibrosis, 10 ng/mL TGF-β1 was used to induce EndMT in human umbilical vein endothelial cells (HUVECs) and a 5 mg/kg/d subcutaneous injection of Isoproterenol (ISO) was used to induce myocardial fibrosis in mice . The drug affinity-responsive target stability (DARTS) was used to identify the target proteins of ASIV in endothelial cells.
View Article and Find Full Text PDFJ Interv Card Electrophysiol
September 2025
Texas Cardiac Arrhythmia Institute, St. David's Medical Center, 3000 N Interstate 35, Suite 700, Austin, TX, 78705, USA.
Background: Dedicated radiofrequency (RF) needles and wires for transseptal puncture (TSP) achieve better outcomes vs. electrified open-ended needles and guidewires due to optimized electrode design and energy delivery. This study benchmarked TSP performance between the dedicated VersaCross wire system (VC; Boston Scientific) and an electrified guidewire with an alternative electrode configuration similar to commercially available devices.
View Article and Find Full Text PDFJ Fish Biol
September 2025
Department of Biological Sciences, University of New Brunswick - Saint John, Saint John, New Brunswick, Canada.
Many Arctic fishes experience prolonged periods of extreme cold and large thermal variation over both rapid and seasonal time scales which challenge critical physiological functions. In the central Canadian Arctic, we caught wild adult lake trout (Salvelinus namaycush) acclimatized to winter and summer temperatures to determine the extent to which they seasonally adjust cardiac thermal performance and adrenergic control. We assessed the intrinsic and maximum heart rate (f and f) of anaesthetised fish through cholinergic blockade and either adrenergic blockade (f) or stimulation (f) during acute warming.
View Article and Find Full Text PDFJ Appl Physiol (1985)
September 2025
Thermal and Mountain Medicine Division, U.S. Army Research Institute of Environmental Medicine, Natick, MA, USA.
Individuals who work in the heat, such as military personnel and athletes, are often required to rapidly transition from temperate or cooler climates to hot environments. Thus, acclimation strategies are needed for individuals lacking access to hot weather. We sought to develop and validate a practical exercise with overdressing protocol for heat acclimation.
View Article and Find Full Text PDFACS Appl Mater Interfaces
September 2025
Core Manufacturing Technology Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba Central 5, 1-1-1 Higashi, Tsukuba, Ibaraki 305-8565, Japan.
The direct deposition of piezoelectric ceramic thin films onto metal foils has become a significant challenge due to the increasing demand for embedded decoupling capacitors, nanogenerators, and flexible piezo-sensors. However, traditional thermal sintering (TS) methods present several issues for metal foils, including alterations in mechanical properties, the formation of wrinkles, and the need for precise control over the sintering atmosphere to prevent oxidation. In this study, we successfully crystallized BaTiO on a Ni foil under atmospheric conditions, mitigating thermal damage to the foil through a hybrid-solution-incorporated photoassisted chemical solution deposition (HS-PCSD) method.
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