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The social relations model (SRM) is a linear random-effects model applied to examine dyadic round-robin data within social networks. Such data have a unique multilevel structure in that dyads are cross-classified within individuals who may be nested within different social networks. The SRM decomposes perceptual or behavioral measures into multiple components: case-level random effects (in-coming and out-going effects) and dyad-level residuals (relationship effects), the associations among which are often of substantive interest. Multivariate SRM analyses are increasingly common, requiring more sophisticated estimation algorithms. This article evaluates Markov chain Monte Carlo (MCMC) estimation of multivariate-SRM parameters, compares MCMC to maximum-likelihood estimation, and introduces two methods to reduce bias in MCMC point estimates using empirical-Bayes priors. Four simulation studies are presented, two of which reveal dependency of small-group results on priors by manipulating location and precision hyperparameters, respectively. The third simulation study explores the impact of sampling more small groups on prior sensitivity. The fourth simulation study explores how Bayesian model averaging might compensate for underestimated variance due to empirical-Bayes priors. Finally, recommendations for future research are made and extensions of the SRM are discussed.
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http://dx.doi.org/10.1080/00273171.2025.2496507 | DOI Listing |
Bayesian Anal
January 2025
Department of Statistics, University of Washington, Seattle, USA.
We introduce the BREASE framework for the Bayesian analysis of randomized controlled trials with binary treatment and outcome. Approaching the problem from a causal inference perspective, we propose parameterizing the likelihood in terms of the aseline isk, fficacy, and dverse ide ffects of the treatment, along with a flexible, yet intuitive and tractable jointly independent beta prior distribution on these parameters, which we show to be a generalization of the Dirichlet prior for the joint distribution of potential outcomes. Our approach has a number of desirable characteristics when compared to current mainstream alternatives: (i) it naturally induces prior dependence between expected outcomes in the treatment and control groups; (ii) as the baseline risk, efficacy and risk of adverse side effects are quantities commonly present in the clinicians' vocabulary, the hyperparameters of the prior are directly interpretable, thus facilitating the elicitation of prior knowledge and sensitivity analysis; and (iii) we provide analytical formulae for the marginal likelihood, Bayes factor, and other posterior quantities, as well as an exact posterior sampling algorithm and an accurate and fast data-augmented Gibbs sampler in cases where traditional MCMC fails.
View Article and Find Full Text PDFBioinformatics
September 2025
Institute of Ecology and Evolution, University of Edinburgh, Edinburgh, United Kingdom.
Summary: In Bayesian phylogenetic and phylodynamic studies it is common to summarise the posterior distribution of trees with a time-calibrated summary phylogeny. While the maximum clade credibility (MCC) tree is often used for this purpose, we here show that a novel summary tree method-the highest independent posterior subtree reconstruction, or HIPSTR-contains consistently higher supported clades over MCC. We also provide faster computational routines for estimating both summary trees in an updated version of TreeAnnotator X, an open-source software program that summarizes the information from a sample of trees and returns many helpful statistics such as individual clade credibilities contained in the summary tree.
View Article and Find Full Text PDFStat Med
September 2025
Department of Physical Therapy, University of Florida, Gainesville, Florida, USA.
The goal of this paper is to estimate an optimal combination of biomarkers for individuals with Duchenne muscular dystrophy (DMD), which provides the most sensitive combinations of biomarkers to assess disease progression (in this case, optimal with respect to standardized response mean (SRM) for 4 muscle biomarkers). The biomarker data is incomplete (missing and irregular) multivariate longitudinal data. We propose a normal model with structured covariance designed for our setting.
View Article and Find Full Text PDFBMC Med Res Methodol
September 2025
Department of Statistics, University of Pretoria, Pretoria, South Africa.
Background: Joint modeling is widely used in medical research to properly analyze longitudinal biomarkers and survival outcomes simultaneously and to guide appropriate interventions in public health. However, such models become increasingly complex and computationally intensive when accounting for multiple features of these outcomes. The need for computationally efficient methods in joint modeling of competing risks survival outcomes and longitudinal biomarkers is particularly critical in clinical and epidemiological settings, where prompt decision-making is essential.
View Article and Find Full Text PDFInd Eng Chem Res
August 2025
School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, Atlanta, Georgia 30332, United States.
Pervaporation, combined with other separation processes, can effectively remove water from fermentation product streams, making it highly suitable for purifying alcohols like 2,3-butanediol (BDO). In this study, a dense poly-(vinylidene fluoride) (PVDF) hollow fiber membrane module prototype was fabricated for BDO dehydration, achieving >0.2 LMH total flux and >95% BDO rejection.
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