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Extreme heat is worsening due to climate change, and, in combination with increasing urban growth, is an escalating public health concern. In the Arabian Peninsula, the wet-bulb temperature is projected to surpass theoretical human tolerance limits during the 21st century. Yet, heat research in the region has generally not focused on health impacts, and it is unclear how epidemiologic literature has investigated this. We performed a scoping review to examine the existing literature that assessed the relationship between extreme heat and health outcomes in the Arabian Peninsula, collecting papers published from 2010 to 2024 from three databases. We identified and extracted detailed information from a limited number of studies ( = 12). The greatest number of studies were conducted in Kuwait ( = 8), with others in Saudi Arabia ( = 4), and Qatar, Oman, Yemen, and the United Arab Emirates ( = 1 each). Average temperature was the most used exposure ( = 9) assessed at the daily level ( = 10), using one or several meteorological stations ( = 9) from a single city ( = 8). The outcome was predominantly daily-level ( = 10) mortality ( = 9) assessed at an ecological scale ( = 10) as opposed to the individual scale. While most studies included confounders ( = 10), their selection was not always consistent with best practices. Most papers did not assess effect modification ( = 8), and none investigated modification by land-cover and land-use change on the heat-health relationship. We provide future research recommendations based on our findings. Additional studies are critical to better understand the heat-health relationship in the Arabian Peninsula, which can aid intervention implementation.
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http://dx.doi.org/10.1029/2024GH001277 | DOI Listing |
Clin J Am Soc Nephrol
September 2025
University College London Great Ormond Street Hospital for Children and Institute of Child Health, London, UK.
Background: Experience with icodextrin use in children on long-term peritoneal dialysis is limited. We describe international icodextrin prescription practices and their impact on clinical outcomes: ultrafiltration, blood pressure control, residual kidney function (RKF), technique and patient survival.
Methods: We included patients under 21 years enrolled in the International Pediatric Peritoneal Dialysis Network (IPPN) between 2007 and 2024, on automated PD with a daytime dwell.
J Clin Invest
September 2025
Department of Clinical and Biomedical Sciences, Faculty of Health and Life Sciences, University of Exeter, Exeter, United Kingdom.
Understanding the genetic causes of diseases affecting pancreatic β cells and neurons can give insights into pathways essential for both cell types. Microcephaly, epilepsy and diabetes syndrome (MEDS) is a congenital disorder with two known aetiological genes, IER3IP1 and YIPF5. Both genes encode proteins involved in endoplasmic reticulum (ER) to Golgi trafficking.
View Article and Find Full Text PDFCell Biochem Biophys
September 2025
School of Natural Sciences, Macquarie University Sydney, Macquarie Park, NSW, Australia.
Folia Microbiol (Praha)
September 2025
Soil Science Division, Bangladesh Wheat and Maize Research Institute, Dinajpur, 5200, Bangladesh.
The aim of the study was to reduce the chemical fertilizers with microbial inoculant-rich vermicompost, which enhanced the growth, flowering, and soil health of the tuberose crop. A total of six treatments were applied with reducing doses of synthetic fertilizers under a factorial randomized design and replicated thrice. In this study, vermicompost (VC) made from cow dung and vegetable waste utilizing Eisenia foetida and their mixed biomass were enriched with microbial inoculants and assessed for their impact on microbial and enzymatic populations including urease, acid phosphatase activity and dehydrogenase activity in soil, nutrient availability, and tuberose development and flowering.
View Article and Find Full Text PDFMol Divers
September 2025
Department of Chemistry, College of Science, King Khalid University, P.O. Box 9004, 61413, Abha, Saudi Arabia.
The catalytic asymmetric Mannich reaction is a multicomponent reaction which affords β-amino carbonyl compounds by utilizing an aldehyde, a primary or secondary amine/ammonia, and a ketone. β-amino carbonyl scaffolds are crucial intermediates for the synthesis of naturally occurring bioactive compounds and their derivatives. The synthesized natural compounds exhibit a broad spectrum of biological activities including anti-fungal, anti-cancer, anti-bacterial, anti-HIV, anti-oxidant, and anti-inflammatory activities.
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