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Products often end up in landfills after serving their purpose, e.g. after their end-of-life. While some parts can be/sometimes are salvaged for valuable materials like rare earth elements, the majority are discarded-a common but wasteful practice. The concept of circular economy promotes recycling or recovering to maximize resource efficiency and to avoid landfill from end-of-life products, though often sub-optimally. Our method introduces a simple, yet novel, concept grounded in circular economy principles to extend the lifespan of end-of-life products' components. The product is disassembled, and components are grouped based on their susceptibility to wear and tear. Using a 360° visual diagnostic tool, individual components are then categorized as either healthy with reduced remaining-useful-life or having reached end-of-life. Appropriate R-strategies such as reuse, repurpose, refurbish, remanufacture, recycle, and recover are subsequently applied, extending the lifespan of the component. The proof-of-concept for the 360° visual diagnostic tool is validated using a product from a Swedish outdoor power product manufacturer.•Focus on end-of-life products not originally designed with circular economy principles.•Expands R-strategies from recycle and recover to reuse, repurpose, refurbish, remanufacture, recycle and recover for end-of-life products.•Provides practitioners with a decision-making tool to estimate component-level circularity and identify end-of-life strategies.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12209887 | PMC |
http://dx.doi.org/10.1016/j.mex.2025.103423 | DOI Listing |
Open Res Eur
September 2025
Veterinary and Animal Sciences, University of Copenhagen, Frederiksberg, 1870, Denmark.
Background: Innovative antibiotic discovery strategies are urgently needed to successfully combat infections caused by multi-drug-resistant bacteria.
Methods: We employed a direct screening approach to identify compounds with antimicrobial and antimicrobial helper-drug activity against Gram-positive and Gram-negative bacteria. We used this platform in two different strains of methicillin-resistant (MRSA) and aminoglycoside-resistant strains of to screen for antimicrobials compounds, which potentiate the activity of aminoglycoside antibiotics.
J Toxicol Environ Health A
September 2025
Department of Sciences, University of Franca, Franca, São Paulo, Brazil.
Pediatric high-grade gliomas remain a significant therapeutic challenge due to their resistance to conventional treatments. The aim of this study was to investigate the cytotoxic potential of solamargine (SM), a natural glycoalkaloid, alone and in combination with the chemotherapeutic agent temozolomide (TMZ) against the human KNS-42 glioma cell line. Solamargine significantly reduced cell viability and proliferation in a concentration-, time-, and hypoxia-dependent manner, while selectively sparing non-tumor human astrocytes (NHA).
View Article and Find Full Text PDFJ Am Chem Soc
September 2025
Department of Chemistry, University of Zurich, CH-8057, Zurich, Switzerland.
Paraptosis is a distinct form of programmed cell death characterized by cytoplasmic vacuolization, mitochondrial swelling, and endoplasmic reticulum (ER) dilation, offering an alternative to apoptosis for therapeutic applications. In this study, we identified a hemicyanine derivative that is a potent paraptosis inducer in two cancer cell lines. This compound triggers hallmark paraptotic features, including ER swelling, mitochondrial morphological changes, increased superoxide production, and caspase-independent cell death.
View Article and Find Full Text PDFBr J Haematol
September 2025
Department of Hematology, The First Affiliated Hospital of University of Science and Technology of China, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China.
Refractory cytomegalovirus (CMV) infection is a severe complication following umbilical cord blood transplantation (UCBT). Antiviral agents, the standard first-line therapy, are limited by toxicity and resistance without robust T-cell immunity. We evaluated third-party donor (TPD)-derived CMV-specific T cells (CMVSTs) as a treatment option.
View Article and Find Full Text PDFStem Cell Rev Rep
September 2025
Paris Cité University, INSERM UMR-S 970, Paris Cardiovascular Research Centre, Paris, France.
Endothelial Colony-Forming Cells (ECFCs) are recognized as key vasculogenic progenitors in humans and serve as valuable liquid biopsies for diagnosing and studying vascular disorders. In a groundbreaking study, Anceschi et al. present a novel, integrative strategy that combines ECFCs loaded with gold nanorods (AuNRs) to enhance tumor radiosensitization through localized hyperthermia.
View Article and Find Full Text PDF