Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Sedentary behavior is widely recognized as a detriment to health. Limited conclusions have been drawn about the relationship between sitting time and biomarkers-measured aging. 12,504 eligible adults were included from the National Health and Nutrition Examination Survey (NHANES) 2007 to 2016. Weighted logistic regression, subgroup analysis, and restricted cubic spline regression were conducted to investigate the association and dose-response relationship between sitting time and phenotypic age acceleration (PhenoAgeAccel). The mediating effect of body mass index (BMI) on this correlation was revealed by mediation analysis. After adjusting for multiple covariates, longer sitting time (4-6 h: OR 1.30, 95%CI 1.06-1.58, p = 0.013; 6-8 h: OR 1.25, 95%CI 1.01-1.55, p = 0.038; ≥8 h: OR 1.58, 95%CI 1.33-1.88, p < 0.001) significantly had higher risk of aging comparing to the reference (< 4 h). The dose-response relationship exhibited an approximately linear dependence. Additionally, BMI partially mediated the association between sitting time and PhenoAgeAccel by a 21.0% proportion. Our study revealed a strong, significant, independent, linear relationship between sitting time and phenotypic age. BMI served as a mediator of the correlation between sitting time and PhenoAgeAccel.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12219758 | PMC |
| http://dx.doi.org/10.1038/s41598-025-06325-x | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Associations between cognitive function and vascular health in office-based sedentary workers: A six-month yoga intervention.
J Educ Health Promot
July 2025
Department of Radiodiagnosis and Imaging, Kasturba Medical College Manipal, Manipal Academy of Higher Education, Manipal, Karnataka, India.
Background: Sedentary office work poses risks to physical and cognitive health. This study investigated the effects of a 6-month yoga intervention on sedentary office workers' cognitive function and vascular parameters.
Materials And Methods: Twenty-four office workers (mean age 26.
Physical Activity and Exercise Patterns of Submariners in Land and Sea Environments.
Mil Med
September 2025
School of Medical and Health Sciences, Edith Cowan University, Joondalup, WA 6027, Australia.
Introduction: Submarine environments pose unique challenges to maintaining physical activity and exercise routines due to confined spaces, demanding schedules, and limited resources. This study investigated submariners' physical activity patterns, sleep quality, and perceived exercise barriers in both land- and sea-based settings, with the goal of informing targeted health interventions.
Materials And Methods: Ethics approval was granted by the Defence Science and Technology Group and Edith Cowan University review panels.
Purpose: The aim of this study was to investigate the effects of 3 months of seated Tai Chi (TC) practice on the eye-hand coordination and sitting balance control of subjects with Parkinson's disease.
Method: A prospective non-randomized study was conducted with 29 subjects practicing TC and 27 subjects as controls according to their preference. The seated TC group underwent 3 months of training with a total of 24 sessions (1hour/session, 2 sessions/week).
Musculoskeletal Pain in Pediatric Surgeons: Prevalence, Impact, and Prevention-A Cross-Sectional Survey Study.
Eur J Pediatr Surg
September 2025
Department of Pediatric Surgery, Dr. von Hauner Children´s Hospital, University Hospital, LMU Munich, Germany.
Recent studies show that at least three-quarters of surgeons who perform minimally invasive surgery suffer from musculoskeletal pain and discomfort. This problem may compromise surgical performance, patient outcomes, and career longevity. Because of small patient dimensions, pediatric surgery is associated with a different set of ergonomic challenges than adult surgery.
View Article and Find Full Text PDFSmartphone use on the toilet and the risk of hemorrhoids.
PLoS One
September 2025
Division of Gastroenterology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States of America.
Smartphones are ubiquitous in daily life, with many people now using them while sitting on the toilet. Despite anecdotal evidence that length of time spent on the toilet is a risk factor for hemorrhoids, a multivariate analysis of smartphone use has not been performed. This study examines the correlation between smartphone use on the toilet and prevalence of hemorrhoids.
View Article and Find Full Text PDF