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Collective behaviors in groups emerge from complex webs of direct and indirect interactions among individuals. While pairwise interactions are fundamental to understanding group dynamics, each agent's historical trajectory confounds causal inference, making it challenging to disentangle direct interactions from those mediated by hidden intermediaries. Here, we address the question: given observational tracking data from only a single pair of agents, can we determine whether their interaction is direct or mediated by an unseen third agent? We propose a framework based on modified transfer entropy analysis across delay times to detect the presence of a hidden intermediary. Our approach reveals a distinct signature: direct interactions exhibit a consistently decreasing modified transfer entropy with increasing delay time, whereas indirect interactions deviate from this trend. This method provides a simple yet versatile tool for uncovering hidden structures in complex systems, with broad implications for networked dynamics in biological, social, and artificial systems.
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http://dx.doi.org/10.1038/s41598-025-04436-z | DOI Listing |
Sci Justice
September 2025
College of Science and Engineering, Flinders University, Bedford Park, South Australia, Australia.
DNA transfer events have been well researched in the context of commonly found items at crime scenes. However, whilst animals are a common feature of most households, transfer events involving companion animals have been understudied. Recent research has shown that dogs and cats are a reservoir of human DNA that can transfer to a hand or sterile object after a short contact.
View Article and Find Full Text PDFDev Cell
September 2025
Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK. Electronic address:
Lineage specification requires accurate interpretation of multiple signaling cues. However, how combinatorial signaling histories influence fate outcomes remains unclear. We combined single-cell transcriptomics, live-cell imaging, and mathematical modeling to explore how activin and bone morphogenetic protein 4 (BMP4) guide fate specification during human gastrulation.
View Article and Find Full Text PDFJMIR Rehabil Assist Technol
September 2025
Department of Computer Science, Faculty of Technology, Art and Design, OsloMet - Oslo Metropolitan University, Oslo, Norway.
Background: Over the past decade, the proportion of the world's population aged ≥65 years has grown exponentially, presenting significant challenges, such as social isolation and loneliness among this population. Assistive technologies have shown potential in enhancing the quality of life for older adults by improving their physical, cognitive, and communication abilities. Research has shown that smart televisions are user-friendly and commonly used among older adults.
View Article and Find Full Text PDFVector Borne Zoonotic Dis
September 2025
Laboratory of Veterinary Internal Medicine, BK21 FOUR Future Veterinary Medicine Leading Education and Research Center, Research Institute for Veterinary Science and College of Veterinary Medicine, Seoul National University, Seoul, Republic of Korea.
The zoonotic infectious disease, severe fever with thrombocytopenia syndrome (SFTS), caused by the SFTS virus (SFTSV), , was first identified in China in 2009 and reported in the Republic of Korea in 2013. The primary vector is the tick (.) , which is endemic to the Asia-Pacific region and has a wide range of hosts.
View Article and Find Full Text PDFNat Sci Sleep
September 2025
Department of Geriatrics, Tianjin Medical University General Hospital; Tianjin Key Laboratory of Elderly Health; Tianjin Geriatrics Institute, Tianjin, People's Republic of China.
Background: Sleep and frailty are established influencing factors for cardiometabolic diseases (CMDs). However, their joint effects on cardiometabolic multimorbidity (CMM) in older adults remain poorly understood. This study aimed to assess the joint effect of sleep health and frailty on CMD prevalence and severity, with an emphasis on subgroup-specific health risk profiles.
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