Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Background: Loneliness is a global public health concern. Investigating loneliness in the general population offers a greater generalizability across various levels of health-related impairments, the identification of at-risk individuals, the detection of different loneliness severity levels, and broader insights into social determinants. Previous studies have shown that loneliness might be a transient or chronic experience, depending on how consistently it is reported across at least two timepoints. This study aimed to assess differential associations of chronic and transient with various domains of psychopathology.
Methods: Participants were enrolled from the general population and assessed at two timepoints spanning 6-7 months. Depressive symptoms, generalized anxiety, social anxiety, and paranoid thoughts were measured using self-reports. The data were analyzed using binary logistic regressions.
Results: Altogether, 3,275 participants completed both assessments with a retention rate of 64.2%. Chronic loneliness was associated with higher baseline and follow-up scores across all symptom domains. The strongest association was observed for social anxiety. Transient loneliness was not robustly associated with symptom scores. It was not significantly associated with depressive symptoms (at either of timepoints) and paranoid ideation (at baseline). The strongest association was observed for generalized anxiety. Chronic loneliness, compared to transient loneliness, was associated with significantly higher odds of social anxiety, depressive symptoms, and paranoid ideation, but not generalized anxiety.
Conclusions: Both transient and chronic loneliness are associated with mental health outcomes, with the latter one showing generally stronger associations. Risk stratification and early intervention among individuals experiencing loneliness might be needed to prevent the development of more severe psychopathology.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12303777 | PMC |
| http://dx.doi.org/10.1192/j.eurpsy.2025.10055 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Vanadium shows no effect in stress-induced hyperthermia and the tail suspension test in healthy mice.
J Trace Elem Med Biol
September 2025
Department of Neurobiology, Maj Institute of Pharmacology, Polish Academy of Sciences, Smętna 12, Kraków 31-343, Poland. Electronic address:
Vanadium (V) is a trace element in the environment; it is detected in soil, water, air, dust, and food products. V-containing compounds have shown therapeutic potential in the treatment of diabetes. However, studies on the effects of V on animal behavior remain limited and sporadic.
View Article and Find Full Text PDFTherapists' Role in Patient Adherence to Internet-Based Cognitive Behavioral Therapy: Qualitative Study.
J Med Internet Res
September 2025
Department of Psychiatry, Helsinki University Hospital and Helsinki University, Helsinki, Finland.
Background: Internet-based cognitive behavioral therapies (iCBTs) are typically categorized into 2 types: therapist-assisted and self-guided. Both formats have accumulated substantial evidence supporting their cost-effectiveness and efficacy in treating a range of mental health conditions. However, therapist-assisted iCBTs tend to show lower dropout rates than self-guided versions.
View Article and Find Full Text PDFKey factors underpinning neuroimmune-metabolic-oxidative (NIMETOX) major depression in outpatients: paraoxonase 1 activity, reverse cholesterol transport, increased atherogenicity, protein oxidation, and differently expressed cytokine networks.
Neuro Endocrinol Lett
September 2025
Sichuan Provincial Center for Mental Health, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu 610072, China.
Background: Major depressive disorder (MDD) is associated with neuro-immune - metabolic - oxidative (NIMETOX) pathways.
Aims: To examine the connections among NIMETOX pathways in outpatient MDD (OMDD) with and without metabolic syndrome (MetS); and to determine the prevalence of NIMETOX aberrations in a cohort of OMDD patients.
Methods: We included 67 healthy controls and 66 OMDD patients and we assessed various NIMETOX pathways.
Comparative effectiveness and safety of probiotics with psychotropic potential in mental health benefits in irritable bowel syndrome: a systematic review and network meta-analysis.
Eur J Gastroenterol Hepatol
August 2025
Department of Surgery, Aristotle University of Thessaloniki, Thessaloniki.
Background: The use of probiotics as a treatment for irritable bowel syndrome (IBS) is gaining attention, with recent studies indicating that certain probiotics or combinations may have mental health benefits for patients with IBS.
Aims: To systematically review and meta-analyze, using network meta-analysis (NWM), the comparative effectiveness and safety of probiotics with psychotropic potential on quality of life, depression, and anxiety in patients with IBS.
Methods: Relevant randomized controlled trials (RCTs) were analyzed, using a Bayesian NWM, to compare the performance of probiotics with mental health benefits in IBS treatment.
Perceived barriers to care and access to university mental health support services among first-year undergraduates: findings from the U-Flourish study.
J Am Coll Health
September 2025
Department of Psychiatry, University of Oxford, Oxford, UK.
Objective: Many students who need mental health support do not receive it. We examined associations between perceived barriers and university mental health service access. Participants: First-year Oxford University undergraduates ( = 443) with unmet mental health needs.
View Article and Find Full Text PDF