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Purpose: To design and pilot a tailored intervention to enhance type 2 diabetes mellitus (T2DM) outcomes in an under-resourced Midwestern community. Design: One group pre-post feasibility study guided by Social Cognitive Theory and the Center for Latino Adolescent and Family Health's social determinants of health (SDOH) framework.
Methods: A community-health-academic partnership of three nonprofit organizations, nurses, researchers, and promotoras (community health workers) developed an intervention program to help people in their community prevent and manage T2DM and mitigate adverse SDOH. Seven small group, interactive sessions included low health literacy materials on diabetes-related self-care skills, healthy eating on a limited budget, and linkages to healthful resources and health care.
Findings: Participants (n = 31) had received a new diagnosis of pre-diabetes (n = 14) or T2DM (n = 17) at free community health screenings and were not engaged in care. All self-identified as Hispanic, had low acculturation scores, and were underinsured. After 12 weeks, hemoglobin A1C levels had significantly decreased for 66% of participants (p = 0.012). Body weight decreased from baseline to 12 weeks, although the change was not statistically significant. Self-efficacy for diabetes self-care increased from baseline to 12 weeks, notably on healthy eating (p = .012); exercising regularly (p = .035) and controlling diabetes/blood sugars (p = .003).
Conclusions: The intervention has promise but more research is needed to examine intervention efficacy and strategies to facilitate implementation.
Clinical Evidence: Nurses play an important role in forging partnerships that can equip people in their communities with the knowledge, skills, and strategies to improve their T2DM health outcomes and to help them mitigate adverse SDOH.
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http://dx.doi.org/10.1080/07370016.2025.2522172 | DOI Listing |
Hormones (Athens)
September 2025
Division of Endocrinology, Baltimore VA Medical Center, Baltimore, MD, USA.
Sodium-glucose co-transporter 2 inhibitors (SGLT2i) are a fairly new class of agents for diabetes that have demonstrated significant benefits in glycemic control and cardiovascular outcomes with outpatient use. The aim of this review is to provide an overview of the effect of SGLT2i use on glycemic control and clinical outcomes in the hospital setting.An electronic search of PubMed was conducted to analyze publications that assessed the inpatient use of SGLT2i and included patients with diabetes.
View Article and Find Full Text PDFEndocrine
September 2025
Otorhinolaryngology, Head and Neck Surgery, Candiolo Cancer Institute, FPO-IRCCS Turin, Turin, Italy.
Background: While osteoporosis in primary hyperparathyroidism (PHPT) is widely studied, PHPT patients with osteopenia remain less characterized. This study aimed to evaluate the prevalence, biochemical features, and estimated fracture risk of osteopenic PHPT patients in a real-life cohort.
Methods: We retrospectively analyzed a consecutive series of PHPT patients with available densitometric data at three sites.
Acta Diabetol
September 2025
Department of Endocrinology & Metabolism, Medical College & Hospital, Kolkata, 88, College St. College Square, Kolkata, West Bengal, 700073, India.
Background And Aims: Gestational diabetes mellitus (GDM) is defined as glucose intolerance first identified during pregnancy that does not meet the criteria for overt diabetes. Its pathophysiology shares key features with type 2 diabetes mellitus (T2D), including insulin resistance and inflammation. Emerging evidence suggests that long non-coding RNAs (lncRNAs) are implicated in T2D.
View Article and Find Full Text PDFInfection
September 2025
The Department of Cardiology, Copenhagen University Hospital, Rigshospitalet, Inge Lehmanns Vej 7, 16th floor, Copenhagen, 2100, Denmark.
Purpose: Infective endocarditis (IE) has been associated with severe outcomes when complicated by diabetes mellitus (DM). We aimed to report characteristics, microbial etiology, and mortality for patients with IE stratified by DM from a nationwide cohort.
Methods: We used Danish registries, and patients with first-time IE (2010-2020) were stratified by DM.
Biosci Biotechnol Biochem
September 2025
Department of Nutrition, Graduate School of Human Life and Ecology, Osaka Metropolitan University, Osaka 558-8585, Japan.
Glucagon dysregulation is a hallmark of type 2 diabetes mellitus (T2DM), yet its early hepatic effects remain unclear. Here, we demonstrate that glucagon-induced gluconeogenesis is markedly enhanced in primary hepatocytes from prediabetic Otsuka Long-Evans Tokushima Fatty (OLETF) rats, a well-established model of human T2DM. Compared to control LETO rats, OLETF hepatocytes showed significantly higher glucagon-stimulated expression of gluconeogenic genes (Pepck, G6pase, Fbp1) at both mRNA and protein levels, along with elevated glucose production.
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