98%
921
2 minutes
20
Download full-text PDF |
Source |
---|---|
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12277628 | PMC |
http://dx.doi.org/10.1016/j.jacadv.2025.101783 | DOI Listing |
Heart Rhythm
August 2025
Arrhythmia Center, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China. Electronic address:
Background: Atrial fibrillation (AF) significantly increases stroke, heart failure, and mortality risk. Elevated lipoprotein(a) (Lp[a]) is implicated in AF pathogenesis, but its relationship with systemic inflammation (assessed by high-sensitivity C-reactive protein [hs-CRP]) remains unclear.
Objective: We investigated whether the Lp(a)-AF association is independent of baseline inflammatory status.
Psychoneuroendocrinology
July 2025
Department of Epidemiology and Health Statistics, School of Public Health, Capital Medical University, No.10 Xitoutiao, Youanmen Street, Fengtai District, Beijing 100069, China. Electronic address:
Background: Studies investigating lipid-depression associations have reported inconsistent findings, and few have considered the interrelationships among lipid parameters. Additionally, the moderating role of inflammation in these associations remains unclear. This study aims to (1) assess lipid-depression associations after controlling for other lipid parameters, and (2) explore the moderating effect of inflammation.
View Article and Find Full Text PDFCirc Genom Precis Med
August 2025
Department of Medicine, Harvard Medical School (R.B., A.P., A.J., S.H., K.L., M.C.H., P.N.), Massachusetts General Hospital, Boston.
Background: Prior work suggests modifiable cardiovascular risk factors (CRFs) account for 80% to 90% of the risk for incident myocardial infarction. The contributions of genetic and other novel CRFs have not been simultaneously assessed in contemporary data sets.
Methods: In the United Kingdom Biobank, CRFs were identified and Cox proportional hazards models with traditional CRFs (hypertension, diabetes, dyslipidemia, waist-to-hip ratio, diet, exercise, alcohol, and socioeconomic deprivation) and contemporary/genetic CRFs (Lp(a) [lipoprotein(a)], hsCRP [high-sensitivity C-reactive protein], familial hypercholesterolemia variants, and polygenic risk score for coronary artery disease) were constructed for coronary artery disease.
JACC Adv
June 2025
Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland, Ohio, USA. Electronic address: