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Purpose: The purpose of this study is to evaluate the detection accuracy of a high-definition optical surface imaging (OSI) system for non-coplanar radiotherapy (by rotating a phantom instead of a couch rotation).
Methods: The constancy, reproducibility, and accuracy of the positioning of the OSI system, Catalyst HD (CHD), for non-coplanar treatment were examined by rotating the head phantom around the isocenter. For all the tests, the phantom was rotated by ±30°, ±45°, ±60°, ±90° after correction of the phantom position within 0.0 mm±0.2 mm, and 0.0°±0.1° using Cone Beam CT (CBCT); the CBCT images were acquired again after rotation. We compared the phantom position derived from CHD, translational displacements of the isocenter (Dev.), and rotational displacements (Rot.) to the position derived from CBCT. The constancy of monitoring was evaluated by observing the variation in the isocenter position for 30 min. For evaluating reproducibility, the positions derived from CHD were compared with those from the planning data. The accuracy of positioning was evaluated by comparing CHD and CBCT findings after the couch rotation of ±0.5°.
Results: The constancy test revealed a maximum Rot. of 0.02±0.01° and Dev. of 0.20±0.08 mm, and the reproducibility test showed a maximum Rot. of 0.26±0.15° and Dev. of 0.93±0.26 mm. In the accuracy tests, when the phantom was further rotated by +0.5°, the maximum values were Rot. of 0.73±0.05° and Dev. of 0.35±0.15 mm; at -0.5°, the values were Rot. of -0.37±0.34° and Dev. of 0.43±0.24 mm.
Conclusion: A high-resolution OSI system is useful for position detection during treatment, even in non-coplanar irradiation.
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http://dx.doi.org/10.6009/jjrt.25-1540 | DOI Listing |
Radiother Oncol
August 2025
Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Radiation Oncology, Peking University Cancer Hospital & Institute, Beijing 100142, China. Electronic address:
Objective: To propose and validate a correction method for the respiratory phase shift of using different motion management systems in the 4-dimensional (4D) imaging and free-breathing gated radiotherapy.
Materials And Methods: Synchronized cone-beam CT (CBCT) and optical surface images (OSI) of 30 patients at two institutions were included. Reference diaphragm-signals were extracted from CBCT projections using Amsterdam-Shroud (AS) method.
Molecules
August 2025
Department of Biology, Faculty of Science, University of Ankara, 06000 Ankara, Türkiye.
In this study, extraction conditions were optimized to maximize the biological activities of extracts obtained from , an edible mushroom species. Extraction processes were carried out using an ultrasonically assisted system, and two different optimization approaches were used as follows: Response Surface Methodology (RSM) and Artificial Neural Network-Genetic Algorithm (ANN-GA). The antioxidant potentials of the optimized extracts were evaluated using DPPH, FRAP, TAS, TOS, and OSI parameters; anticholinesterase activities were measured against AChE and BChE enzymes; and antiproliferative activities were investigated in A549, MCF-7, and DU-145 human cancer cell lines.
View Article and Find Full Text PDFBiomedicines
August 2025
Institute of Clinical Chemistry and Biochemistry, University Medical Centre Ljubljana, Zaloška cesta 2, 1525 Ljubljana, Slovenia.
This study investigated the correlation of oxidative stress biomarkers with the activity of idiopathic nephrotic syndrome (INS) in Slovenian children. In this prospective study, sequential plasma and urine samples from 20 children with INS in different phases of disease activity were taken: at first disease presentation or relapse (before glucocorticoid (GC) treatment), at time of remission achievement, and after discontinuation of GC treatment. This study measured oxidative stress biomarkers, such as 8-hydroxy-2'-deoxyguanosine (8-OHdG), hexanoyl-lysine (HEL) adduct, dityrosine (DiY), and 15-isoprostane F2t, using competitive enzyme-linked immunosorbent assay (ELISA) and assessed oxidative status using the FRAS 5 analytical system, which enables rapid photometric measurement of both oxidative and antioxidant capacity from biological fluids.
View Article and Find Full Text PDFFront Public Health
August 2025
Department of Surgery, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia.
Objective: This study aimed to evaluate the efficacy of ankle Kinesio taping (KT) on static and dynamic balance and functional performance in obese female collegiate students.
Design: This study was a prospective, randomized controlled trial.
Setting: The research was conducted in outpatient physical therapy settings.
Am J Phys Med Rehabil
August 2025
Department of Physical Therapy, College of Applied Medical Sciences, Qassim University, Buraydah 51452, P.O. Box 6666, Saudi Arabia.
Objective: To evaluate the efficacy of incorporating Wii Fit-based rehabilitation (WFR) into a conventional physical therapy (CPT) program on balance, functional ability, and fall risk in individuals with chronic ankle instability (CAI).
Design: Single-blinded randomized controlled trial.
Methods: Sixty participants with CAI (aged 18-60 years) were randomly assigned to either an experimental group (WFR plus CPT) or a control group (CPT only).