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Objectives: The purpose of this study was to evaluate inter-segmental foot and ankle kinematics in patients with end-stage lesser tarsometatarsal (TMT) joint arthritis and to identify characteristic gait adaptations using a validated multi-segment foot model.
Methods: Twenty-five patients with radiographically confirmed end-stage lesser TMT arthritis and fifty age- and sex-matched healthy controls underwent three-dimensional gait analysis. A 15-marker DuPont Foot Model was used to capture segmental kinematics of the hallux, forefoot, and hindfoot. Temporal-spatial parameters and inter-segmental motions were compared between groups. Statistical parametric mapping (SPM) was used to assess phase-specific differences across the gait cycle.
Results: The TMT group demonstrated slower walking speeds, shorter stride lengths, and increased step width compared to controls. Significant alterations in inter-segmental kinematics included increased forefoot dorsiflexion and hallux extension during terminal stance, along with reduced sagittal and transverse range of motion (ROM) in the hindfoot and hallux segments. Coronal plane motion was relatively preserved. These findings suggest that sagittal and transverse plane impairments, rather than coronal changes, are predominant in this patient population. Increased forefoot-to-hindfoot motion may reflect medial column laxity, including potential first ray hypermobility, and compensatory adjustments for reduced midfoot stability.
Conclusion: End-stage lesser TMT joint arthritis significantly alters inter-segmental foot motion and spatiotemporal gait parameters. These biomechanical adaptations may reflect compensation for midfoot dysfunction and highlight the importance of addressing sagittal and transverse plane abnormalities in clinical management.
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http://dx.doi.org/10.1016/j.gaitpost.2025.06.017 | DOI Listing |
Curr Opin Endocrinol Diabetes Obes
September 2025
Department of Endocrinology, Bharti Hospital, Karnal, India; University Centre for Research & Development, Chandigarh University, Mohali, India.
Purpose Of Review: Obesity is a global health concern and is intricately linked to cardiovascular disease and metabolic disorders. While its causal association with chronic kidney disease (CKD) has also been recognized, this entity has not been discussed extensively. Obesity-related glomerulopathy (ORG) is pathologically a secondary form of focal segmental glomerulosclerosis (FSGS), which typically presents clinically with subnephrotic proteinuria, and histopathologically as glomerulomegaly, and the perihilar variant of FSGS.
View Article and Find Full Text PDFAm J Gastroenterol
July 2025
Department of Hepatology, Institute of Liver & Biliary Sciences, New Delhi, India.
Introduction: Carvedilol is effective in the prevention of bleeding in patients with cirrhosis and high-risk varices. Although it reduces drivers of clinical decompensation (portal pressure, systemic inflammation, and bacterial translocation), the data on its use for prevention of ascites-related complications are limited.
Methods: In this open-label randomized control tria, patients having uncomplicated new-onset ascites with no or low-risk esophageal varices were randomized (n = 104) to receive carvedilol (group A, n = 52) or no carvedilol (group B, n = 52) in addition to standard treatment.
Gait Posture
September 2025
Department of Orthopaedic Surgery, Seoul National University Hospital, Republic of Korea; Department of Orthopedic Surgery, Seoul National University College of Medicine, Seoul, Republic of Korea. Electronic address:
Objectives: The purpose of this study was to evaluate inter-segmental foot and ankle kinematics in patients with end-stage lesser tarsometatarsal (TMT) joint arthritis and to identify characteristic gait adaptations using a validated multi-segment foot model.
Methods: Twenty-five patients with radiographically confirmed end-stage lesser TMT arthritis and fifty age- and sex-matched healthy controls underwent three-dimensional gait analysis. A 15-marker DuPont Foot Model was used to capture segmental kinematics of the hallux, forefoot, and hindfoot.
Foot Ankle Orthop
April 2025
Julius-Maximilians University Wuerzburg, Department of Orthopaedic Surgery, Koenig-Ludwig-Haus, Wuerzburg, Germany.
Background: Arthroscopic ankle arthrodesis (AAA) is a standard procedure for end-stage osteoarthritis of the ankle. One of the main concerns after AAA remains the development of secondary osteoarthritis in the subtalar and tarsal joints in the long term. This development is thought to be due to a compensatory increased mobility and therefore increased load on the adjacent joints.
View Article and Find Full Text PDFSci Rep
April 2025
Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital, No. 201, Sec. 2, Shih-Pai Road, Taipei, Taiwan.
Chronic total occlusion (CTO) was frequently observed during coronary angiography. Successful revascularization of chronic total occlusion showed controversial result on long-term survival in previous studies. There is scarce report about long-term outcome of successful recanalization of CTO in patients with end stage renal disease (ESRD) receiving renal replacement therapy.
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