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http://dx.doi.org/10.1016/j.jchf.2025.102519 | DOI Listing |
Ann Med Surg (Lond)
September 2025
Department of Surgery B.P. Koirala Institute of Health Sciences, Dharan, Nepal.
Introduction: Surgical errors are a significant concern in medical practice, particularly in teaching institutions where trainees are frequently involved in patient care. These errors, which include deviations from standard surgical procedures, can lead to adverse patient outcomes in one hand whereas emotional distress among surgeons on the other hand as well. Understanding the prevalence, types, and coping mechanisms for surgical errors is essential for developing effective strategies to minimize their occurrence and impact.
View Article and Find Full Text PDFBrain Res Bull
August 2025
Department of Rehabilitation Medicine, Nanfang Hospital, Southern Medical University, PR China; Institute of Brain Diseases, Nanfang Hospital, Southern Medical University, PR China. Electronic address:
Perioperative neurocognitive disorders (PND), encompassing cognitive impairments linked to anesthesia and surgery, significantly impact elderly patients and increase postoperative risks. Intermittent theta burst stimulation (iTBS), a non-invasive neuromodulation protocol, has shown cognitive-enhancing potential in clinical studies. However, its utility for preventing PND remains unexplored.
View Article and Find Full Text PDFBiomacromolecules
September 2025
Fujian Key Laboratory of Drug Target Discovery and Structural and Functional Research, School of Pharmacy, Fujian Medical University, Fuzhou 350122, China.
Chemotherapy is often limited by its low efficacy and severe side effects. Autophagy acts as a double-edged sword where high levels can promote cancer cell death, while low levels induced by chemotherapy can reduce therapeutic effects. Herein, we designed a multifunctional D-type peptide dendrimer as a drug delivery system for chemotherapeutic agents.
View Article and Find Full Text PDFThyroid
August 2025
Division of Endocrinology, Diabetes and Metabolism, Department of Medicine and Department of Physiology, David Geffen School of Medicine at UCLA, Los Angeles, and Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, California, USA.
Traumatic brain injury (TBI) disrupts blood supply, damages neurons and glial cells, and reduces local activation of the prohormone thyroxine (T4) to the active form, triiodothyronine. We treated mice with T4 post-TBI to evaluate the role of thyroid hormone in neural cell protection and injury recovery after TBI, especially the effects on neuroglial cells. A T4 dose was given 1 hour after controlled cortical injury, and in some groups, an additional T4 dose was given 5 days post-TBI.
View Article and Find Full Text PDF