Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Black patients with metastatic prostate cancer have higher mortality rates compared to non-Hispanic White patients. There are no data on outcomes with [Lu]Lu-PSMA-617 (LuPSMA) across racial groups. We evaluated the association between race and outcomes with LuPSMA in a multi-institutional cohort of consecutive patients with mCRPC treated with LuPSMA. The primary outcomes were PSA-50 rate, PSA-progression-free survival (PSA-PFS), and overall survival (OS). Statistical models were adjusted for age, number of prior therapies, sites of metastases, and baseline PSA. A total of 654 patients were included; 593 (91%) were White, 45 (7%) were Black and 16 (2%) were another non-Black minority (NBM). There were no statistically significant differences in PSA-50 rates, PSA-PFS and OS between the groups. Black and White patients treated with LuPSMA had similar clinical outcomes; efforts are needed to ensure Black and NBM patients have equal access to life prolonging therapies to narrow disparities in outcomes.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12191161 | PMC |
| http://dx.doi.org/10.3390/cancers17121960 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Relational accountability in AI-driven pharmaceutical practices: an ethics approach to bias, inequity and structural harm.
J Med Ethics
September 2025
Shrewsbury Public Schools, Shrewsbury, Massachusetts, USA
The integration of artificial intelligence (AI) into pharmaceutical practices raises critical ethical concerns, including algorithmic bias, data commodification and global health inequities. While existing AI ethics frameworks emphasise transparency and fairness, they often overlook structural vulnerabilities tied to race, gender and socioeconomic status. This paper introduces relational accountability-a feminist ethics framework-to critique AI-driven pharmaceutical practices, arguing that corporate reliance on biased algorithms exacerbates inequalities by design.
View Article and Find Full Text PDFValidation of a standardised approach to collect sociodemographic and social needs data in Canadian primary care: cross-sectional study of the SPARK tool.
BMJ Open
September 2025
Upstream Lab, MAP Centre for Urban Health Solutions, Li Ka Shing Knowledge Institute, Unity Health Toronto, Toronto, Ontario, Canada
Objective: This study validates the previously tested Screening for Poverty And Related social determinants to improve Knowledge of and access to resources ('SPARK Tool') against comparison questions from well-established national surveys (Post Survey Questionnaire (PSQ)) to inform the development of a standardised tool to collect patients' demographic and social needs data in healthcare.
Design: Cross-sectional study.
Setting: Pan-Canadian study of participants from four Canadian provinces (SK, MB, ON and NL).
Haploidentical vs. Matched Sibling Donor HCT in Racially Diverse Pediatric and AYA Patients with Hematologic Malignancies: A Single-Center Comparison.
Transplant Cell Ther
September 2025
Department of Pediatrics, University of Arizona, Tucson, AZ, USA; Banner University Medical Center, Tucson, AZ, USA; BIO5 Institute, University of Arizona, Tucson, AZ, USA; The University of Arizona Cancer Center, Tucson, AZ, USA; Department of Immunobiology, University of Arizona, Tucson, AZ, USA;
Background: Allogeneic hematopoietic cell transplantation (allo-HCT) is a potentially curative treatment for pediatric patients with hematologic malignancies. Human leukocyte antigen (HLA)-matched sibling donors (MSDs) are considered the optimal source for stem cell transplantation; however, up to 70% of patients lack an MSD. This disparity is particularly pronounced among racial and ethnic minorities, who face challenges in identifying matched unrelated donors (MUDs).
View Article and Find Full Text PDFCost-effectiveness and health equity improvements from excluding sugar-sweetened beverages from the Supplemental Nutrition Assistance Program.
Am J Prev Med
September 2025
Department of Social and Behavioral Sciences, Harvard T.H. Chan School of Public Health, Boston, Massachusetts.
Introduction: Excluding sugar-sweetened beverages (SSBs) from eligible purchases in the Supplemental Nutrition Assistance Program (SNAP) has been proposed as a strategy to improve diet quality and health. This study estimates the cost-effectiveness of this policy and its potential impact on health equity.
Methods: The Childhood Obesity Intervention Cost Effectiveness Study (CHOICES) microsimulation and systematic review process was used in 2024 to estimate the potential impact of excluding SSBs from SNAP-eligible purchases over a ten-year period (2023-2032) for the U.
Longer-term effects of modernized collaborative care for depression on multiple mental health factors (eIMPACT): A randomized controlled trial.
J Affect Disord
September 2025
Department of Psychology, Indiana University Indianapolis, 402 N. Blackford St., LD 100E, Indianapolis, IN, USA. Electronic address:
Background: Integrating digital mental health into collaborative care could address multiple mental health factors. To determine the longer-term effects of modernized collaborative care for depression on overlapping mental health factors, we analyzed data from the eIMPACT trial.
Methods: Primary care patients with depression and elevated cardiovascular disease risk (N = 216, Mage: 59 years, 78 % female, 50 % Black, 46 % with income <$10,000/year) were randomized to 12 months of the eIMPACT intervention (modernized collaborative care involving internet cognitive-behavioral therapy [iCBT], telephonic CBT, and/or select antidepressants) or usual primary care for depression.