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We describe a case of likely arrhythmic mitral valve prolapse (MVP) resulting in cardiac arrest, cardiopulmonary resuscitation, and initiation of extracorporeal membranous oxygenation. The case provides the clinical stimulus to review what knowledge exists, and what data gaps remain, to guide clinicians toward a proactive approach in managing arrhythmic mitral valve prolapse, a rare but potentially fatal condition. Since MVP is rare, performing several imaging modalities on every patient in whom there is a clinical suspicion would have a low yield. However, raising awareness of concerning features on history, electrocardiogram, and transthoracic echocardiography could improve the utility of more advanced imaging studies.
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http://dx.doi.org/10.1080/08998280.2025.2464465 | DOI Listing |
Front Physiol
August 2025
Department of Electrophysiology, King Abdulaziz Cardiac Center, King Abdullah International Medical Research Center (KAIMRC), MNGHA, King Abdulaziz Medical City, Riyadh, Saudi Arabia.
Background: Mitral valve prolapse (MVP) is a common condition, typically benign, but in a small subset of patients, it may lead to life-threatening arrhythmias and sudden cardiac death (SCD). This arrhythmogenic MVP phenotype is often associated with bileaflet prolapse, mitral annular disjunction (MAD), and myocardial fibrosis identified via late gadolinium enhancement (LGE) on cardiac MRI.
Case Summary: Our patient is a 49-year-old man presented with monomorphic ventricular tachycardia and near-syncope.
Hellenic J Cardiol
August 2025
HEART - Heart Embryology and Anatomy Research Team, Department of Anatomy, Jagiellonian University Medical College, Krakow, Poland; Division of Cardiovascular Sciences, The University of Manchester, UK.
The concept of mitral annular disjunction (MAD) has garnered significant attention due to its potential clinical implications. MAD refers to a spatial displacement of the hinge point of the mitral valve leaflets. Initially described over 150 years ago, MAD has evolved from being an anatomical curiosity to a potential marker of pathological processes, especially in the context of mitral valve prolapse and arrhythmic syndromes.
View Article and Find Full Text PDFMitral valve prolapse (MVP) affects approximately 2.5% of the population and represents the most common cause of primary mitral regurgitation. Mitral regurgitation is related to increased leaflet size, prolapse asymmetry, long clefts, calcification, and restricted leaflet motion.
View Article and Find Full Text PDFJ Thorac Cardiovasc Surg
August 2025
Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH.
Objective: Ventricular arrhythmias occur in a subset of patients with mitral valve prolapse. However, their impact on post-operative survival after degenerative mitral repair is unclear.
Methods: We compared long-term survival after degenerative mitral repair in patients presenting with and without arrhythmic mitral valve prolapse (defined by degenerative mitral regurgitation and ventricular arrhythmias) in a national insurance database.
Am J Cardiol
August 2025
Department of Cardiovascular Medicine, Mayo Clinic Arizona, USA, 85054 ; Department of Clinical Genomics, Mayo Clinic, Phoenix, Arizona, USA, 85054. Electronic address:
Loeys-Dietz syndrome (LDS) is a connective tissue disorder characterized by significant vascular and valvular abnormalities; however, perioperative outcomes involving aortic and valvular interventions remain underreported. This study aimed to evaluate surgical interventions and postoperative complications in LDS patients. We retrospectively reviewed 94 patients diagnosed with LDS from 2018 to 2024 across Mayo Clinic sites.
View Article and Find Full Text PDF