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Pyogenic granuloma (PG) is a benign vascular lesion that manifests as an inflammatory hyperplasia of the skin or mucous membranes. Although termed "pyogenic," PG is not associated with infection; rather, it represents a reactive lesion arising in response to various stimuli such as low-grade local irritation, trauma, or hormonal influences. Clinically, PGs are typically asymptomatic and display variable growth rates. We report the case of a nine-year-old girl referred for evaluation of a gingival mass. Clinical examination revealed a well-defined soft tissue lesion without underlying bone involvement. The patient reported a parafunctional habit of gingival scratching, possibly contributing to the lesion's development, along with a hormonal component given her prepubertal status. Surgical excision of the lesion was performed under local anesthesia using a scalpel, with preservation of the adjacent teeth. Histopathological analysis confirmed the diagnosis of pyogenic granuloma. The differential diagnosis included peripheral giant cell granuloma, peripheral ossifying fibroma, and inflammatory fibrous hyperplasia, highlighting the importance of histological evaluation for accurate diagnosis and appropriate management.
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http://dx.doi.org/10.7759/cureus.84713 | DOI Listing |
Cureus
August 2025
Division of Dermatology, Children's Skin Center, Nicklaus Children's Hospital, Miami, USA.
A 12-month-old female presented with a friable, hemorrhagic papule on the right lateral inferior eyelid, clinically consistent with a pyogenic granuloma. Although pyogenic granulomas are known to bleed, the extent of hemorrhage in this case was unusual and occurred after minor trauma. The patient's father, an emergency medicine resident, injected lidocaine with epinephrine and applied pressure at home to control the bleeding.
View Article and Find Full Text PDFJ Cancer Res Ther
September 2025
Department of Oncology, The First Affiliated Hospital of Shandong First Medical University and Shandong Provincial Qianfoshan Hospital, Shandong Lung Cancer Institute, Jinan, Shandong, China.
Background: This study analyzes adverse event (AE) signals associated with ramucirumab using data from the FDA Adverse Event Reporting System (FAERS) to provide evidence supporting the safety of the drug for clinical use.
Methods: Data were extracted from the FAERS database using Open Vigil 2.1.
Prim Care
September 2025
Department of Community and Family Medicine, University of Missouri Kansas City School of Medicine, University Health Lakewood Medical Center, 7900 Lee's Summit Road, Kansas City, MO 64139, USA. Electronic address:
Benign skin tumors are common findings in primary care. The ability to recognize and diagnose them accurately is important to distinguish them from less common malignant lesions. Dermoscopy and biopsy can improve diagnostic accuracy and streamline dermatologic care.
View Article and Find Full Text PDFACG Case Rep J
August 2025
Philadelphia College of Osteopathic Medicine, Philadelphia, PA.
Pyogenic granulomas (PGs) are benign vascular lesions usually found in the skin and mucous membranes but rarely in the gastrointestinal tract. This case highlights a large PG in the small intestine, causing chronic anemia and serving as a lead point for intussusception. We discuss its diagnostic challenges, potential for misdiagnosis, and treatment options.
View Article and Find Full Text PDFJ Plast Reconstr Surg
July 2025
Department of Plastic and Reconstructive Surgery, Kyorin University School of Medicine, Tokyo, Japan.
Atypical Spitz tumors are one type of the Spitzoid melanocytic lesion, characterized by one or more atypical features, and often demonstrate indeterminate biological potential. Atypical Spitz tumors pose challenges in both clinical and pathological diagnoses. Herein, we report a case of a 1-year-old Japanese girl who presented with a rapidly enlarging lesion mimicking a pyogenic granuloma.
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