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Purpose: To explore the effectiveness of improved Twin block appliances combined with micro-implant anchorage in correction of Class Ⅱ division 1 malocclusion.
Methods: A retrospective analysis of medical records of 96 patients with Class Ⅱ division 1 malocclusion treated at Rugao Hospital of Traditional Chinese Medicine from January 2018 to January 2022 was conducted. The patients were divided into experimental group (n=52) and control group (n=44) based on the treatment methods. The control group was treated with modified Twin-block appliance, while the experimental group was treated with modified Twin-block appliance combined with micro-implant anchorage. Comparison was made between the two groups regarding treatment duration, time to achieve bite opening, alignment time, ANB angle, SNB angle, SNA angle, U1-NA angle, U1-NB angle, U1-SN angle, L1-MP angle, upper lip protrusion(ULP), lower lip protrusion (LLP), Z angle, plaque index (PLI), gingival index (GI) and sulcus bleeding index (SBI). Complications and patient satisfaction were recorded. SPSS 24.0 software package was used for statistical analysis of the data.
Results: The treatment duration, time to achieve bite opening and alignment time in the experimental group were significantly shorter than those in the control group (P<0.05). After treatment, ANB, U1-NA and U1-SN of the two groups were lower than before treatment, and the experimental group was significantly lower than the control group (P<0.05). U1-NB and L1-MP were higher than those before treatment, and the experimental group was significantly higher than the control group (P<0.05). There was no significant difference between SNB and SNA (P>0.05). After treatment, ULP and LLP of the two groups were lower than before treatment, and the experimental group was significantly lower than the control group(P<0.05). Z-angle of the experimental group was significantly higher than that of the control group(P<0.05). PLI in the experimental group was significantly lower than that in the control group (P<0.05). There was no significant difference between GI and SBI (P>0.05), and there was no significant difference in satisfaction between the two groups(P>0.05).
Conclusions: The modified Twin-block appliance combined with micro-implant anchorage can help to shorten the treatment time, improve the jaw and facial soft tissue contour, and promote the recovery of dental aesthetics.
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Histol Histopathol
September 2025
Center for Experimental Teaching, School of Pharmacy, Guangzhou Medical University, Guangzhou, China.
Background: The aim of this study was to establish a rat model of premature ovarian failure (POF) with cyclophosphamide (CTX), and explore the molecular basis of POF and the mechanism of Guishen-Erxian Decoction (GSEXD) to improve POF from the perspective of oxidative stress regulation of ovarian granulosa cell (OGC) DNA fragmentation.
Method: The study utilized SD rats to establish a POF model via CTX. Rats were divided into Control, POF group, three GSEXD dosage groups (low, medium, high), and a GSEXD+PI3K agonist group to assess GSEXD's therapeutic effects on oxidative stress, DNA fragmentation and ovarian damage.
J Am Acad Audiol
September 2025
Given the evidence of cognitive deficits in individuals with vestibular dysfunction, reduced cognitive resources may impact the effort required to process auditory information, particularly in adverse listening conditions. Although existing literature suggests impaired performance on cognitive tasks in vestibular disorders in general, research in this area specific to patients with vestibular migraine is limited. This article aims to investigate working memory, auditory attention, and listening effort among individuals with vestibular migraine.
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September 2025
Intensive Care Unit, Dongguan Traditional Chinese Medicine Hospital, Dongguan, Guangdong Province, China.
This study aimed to evaluate the quality of multidisciplinary team (MDT) management in healthcare-associated infection (HAI) prevention and control, as well as its impact on multidrug-resistant organism (MDRO) infections. This was a retrospective, single-center study with a small sample size. A total of 400 patients admitted to the Departments of Critical Care Medicine or Orthopedics between January 2022 and December 2023 were divided into a control group (n = 200, receiving conventional HAI management) and an experimental group (n = 200, undergoing MDT management).
View Article and Find Full Text PDFIntroduction: Pressure injuries (PIs) in patients with diabetes mellitus (DM) still impacts patients' health and places a heavy burden on healthcare systems. Stage I and stage II PIs are particularly prevalent among individuals with diabetes. Without timely and appropriate interventions, these injuries can progress to more severe stages, requiring prolonged recovery periods.
View Article and Find Full Text PDFBorderline Personal Disord Emot Dysregul
September 2025
German Center for Mental Health (DZPG), partner site Munich, Munich, Germany.
Background: Emotion dysregulation is a central feature in trauma-associated disorders such as posttraumatic stress disorder (PTSD) and borderline personality disorder (BPD). However, it remains unclear whether emotion dysregulation is a transdiagnostic phenomenon closely linked to childhood trauma, or if disorder-specific alterations in emotion processing exist. Following a multimethodological approach, we aimed to assess and compare the reactivity to and regulation of emotions between patients with BPD and PTSD, as well as healthy controls, and identify associations with childhood trauma.
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