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Degenerative cervical myelopathy (DCM) is a common condition with a prevalence of 24.2% in the healthy population, and 35.3% in patients older than 60 years. The management of this clinical condition is difficult and implies chronic management of patients. The risk of drug abuse is very high and may lead to important long-term consequences. Finding a therapeutic option capable to reduce the number of prescribed drugs and with few side effects is very important in DCM. We report a 44-year-old Caucasian woman who was diagnosed with DCM. Her medical history revealed that despite using multiple medications, she did not show any signs of improvement. She declined the surgical treatment as well. Following clinical assessment, a diamagnetic pump treatment with pulsed electromagnetic fields for 3 months (once-twice weekly for 30 min, magnetic flux density 86 mt at the site of treatment) resulted in a clinical improvement. The benefits of diamagnetic therapy were three-faced including pain improvement, functional status, and imaging (magnetic resonance imaging (MRI) showing bone marrow edema reduction and myelopathy improvement). This is the first case report in our knowledge to prove the effectiveness of diamagnetic therapy in DCM, alongside imaging and functional improvement.
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http://dx.doi.org/10.1080/17581869.2025.2523729 | DOI Listing |
Pain Manag
July 2025
Operative Unit of Pharmacology and Pharmacovigilance, "Renato Dulbecco" University Hospital, Catanzaro, Italy.
Degenerative cervical myelopathy (DCM) is a common condition with a prevalence of 24.2% in the healthy population, and 35.3% in patients older than 60 years.
View Article and Find Full Text PDFNeuroimage Clin
May 2025
Department of Radiology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea; Institute for Precision Health, University of California, Irvine, Irvine, CA 92697, United States. Electronic address:
Objectives: Susceptibility source-separation (χ-separation) MRI provides in-vivo proxy of myelin (diamagnetic susceptibility, χ) and iron concentrations (paramagnetic susceptibility, χ) in the central nervous system, potentially uncovering myelin- and iron-related pathology in multiple sclerosis (MS) lesions (e.g., demyelination, remyelination, and iron-laden microglia/macrophages formation).
View Article and Find Full Text PDFSci Rep
January 2025
Department of Chemistry, School of Advanced Sciences, Vellore Institute of Technology, Vellore, Tamil Nadu, 632014, India.
Hydroxyapatite (HA) is an important constituent of natural bone. The properties of HA can be enhanced with the help of various ionic substitutions in the crystal lattice of HA. Iron (Fe) is a vital element present in bones and teeth.
View Article and Find Full Text PDFZool Res
July 2024
High Magnetic Field Laboratory, CAS Key Laboratory of High Magnetic Field and Ion Beam Physical Biology, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei, Anhui 230031, China.
Amyloid beta (Aβ) monomers aggregate to form fibrils and amyloid plaques, which are critical mechanisms in the pathogenesis of Alzheimer's disease (AD). Given the important role of Aβ1-42 aggregation in plaque formation, leading to brain lesions and cognitive impairment, numerous studies have aimed to reduce Aβ aggregation and slow AD progression. The diphenylalanine (FF) sequence is critical for amyloid aggregation, and magnetic fields can affect peptide alignment due to the diamagnetic anisotropy of aromatic rings.
View Article and Find Full Text PDFJ Inorg Biochem
September 2024
NMR Centre, Ruđer Bošković Institute, Zagreb, Croatia. Electronic address:
Wet synthesis approach afforded four new heteroleptic mononuclear neutral diamagnetic oxidovanadium(V) complexes, comprising salicylaldehyde-based 2-furoic acid hydrazones and a flavonol coligand of the general composition [VO(fla)(L-ONO)]. The complexes were comprehensively characterized, including chemical analysis, conductometry, infrared, electronic, and mass spectroscopy, as well as 1D H and proton-decoupled C(H) NMR spectroscopy, alongside extensive 2D HH COSY, HC HMQC, and HC HMBC NMR analyses. Additionally, the quantum chemical properties of the complexes were studied using Gaussian at the B3LYP, HF, and M062X levels on the 6-31++g(d,p) basis sets.
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