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http://dx.doi.org/10.1016/S0140-6736(25)01110-9 | DOI Listing |
Compr Physiol
October 2025
Department of Internal Medicine, University of Iowa, Iowa City, IA, USA.
The median life expectancy of people with Down syndrome has increased substantially over the past several decades, from 4 years in 1970 to 53 years in 2010. Despite the recent improvement in survival, there is little data about the prevalence of age-related diseases, including age-related malignancies, and the impact of standard cancer treatments on cardiovascular health. We retrospectively reviewed medical records for age- and sex-matched patients ≥ 15 years old with and without Down syndrome using the TriNetX platform to identify the prevalence of malignancies and explore cardiovascular outcomes after treatment with anthracyclines.
View Article and Find Full Text PDFEur J Pediatr
September 2025
Department of Occupational Disease Prevention and Control, Jiangsu Provincial Center for Disease Control and Prevention (Jiangsu Provincial Academy of Preventive Medicine), Nanjing, Jiangsu Province, China.
Unlabelled: Long-term lead exposure damages the central nervous system, with chronic poisoning strongly linked to intellectual developmental disability (IDD) and disproportionately affecting children and adolescents. Using the Global Burden of Disease (GBD) 2021 database, this study analyzed temporal, spatial, and population-specific trends in lead-attributable IDD burden among global children/adolescents (1990-2021) and projected trends to 2040 to inform global public health strategies. GBD 2021 data characterized global, regional, and national distributions of lead-attributable IDD burden.
View Article and Find Full Text PDFPLoS One
September 2025
University of Glasgow, Glasgow, United Kingdom.
Background: Open tibia fractures result in substantial lifelong disability for patients, and are expensive to treat. As the injury typically affects young working men, the societal costs from open tibia fractures are likely to also be high in low income countries, but remain largely unknown. We therefore investigated the overall societal costs and cost-effectiveness of different orthopaedic treatments at one year following an open tibia fracture in Malawi.
View Article and Find Full Text PDFJ Elder Abuse Negl
September 2025
Department of Internal Medicine, Kirk Kerkorian School of Medicine at UNLV, Las Vegas, Nevada, USA.
Although health care access among adults with Intellectual and Developmental Disabilities (IDD) improved in the past decade, persistent challenges still exist in obtaining care coordination and supportive services. As the life expectancy of individuals living with IDD increases and care succession occurs from family's community care to institutional care, the risk of maltreatment among adults with IDD is growing. Health conditions, for example, cognitive impairment pose a risk of maltreatment in adults with IDD.
View Article and Find Full Text PDFAnn Med
December 2025
Department of Gastroenterology and Hepatology, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, China.
Background: Gastrointestinal cancers account for 39.0% of global cancer-related deaths. The rising incidence of early-onset gastrointestinal cancers poses a substantial public health challenge due to their aggressive nature and poor prognosis.
View Article and Find Full Text PDF