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Structural priming - a change in processing after repeated exposure to a syntactic structure - has been put forward as evidence for the psychological reality of constituent structures derived from grammar. However, converging evidence from memory research, large language models (LLMs), and structural priming itself challenges the validity of mapping structural representations onto grammatical constituents and demonstrates structural priming in the absence of such structure. Instead of autonomous representations specified by grammar, we propose that contextual representations emerging from multiple constraints (e.g., words, prosody, gesture) underlie structural priming. This perspective accounts for existing anomalous findings, is supported by the strong dependence on lexical cues observed in structural priming, and suggests that future research should prioritize studying linguistic representations in more naturalistic contexts.
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http://dx.doi.org/10.1016/j.tics.2025.05.016 | DOI Listing |
Front Mol Biosci
August 2025
Department of Environmental Science, University of Arizona, Tucson, AZ, United States.
Introduction: Peatlands store up to a third of global soil carbon, and in high latitudes their litter inputs are increasing and changing in composition under climate change. Although litter significantly influences peatland carbon and nutrient dynamics by changing the overall lability of peatland organic matter, the physicochemical mechanisms of this impact-and thus its full scope-remain poorly understood.
Methods: We applied multimodal metabolomics (UPLC-HRMS, H NMR) paired with C Stable Isotope-Assisted Metabolomics (SIAM) to track litter carbon and its potential priming effects on both existing soil organic matter and carbon gas emissions.
Palliat Med Rep
May 2025
Department of Supportive Care, Division of Palliative Care, University Health Network, Toronto, Canada.
Background: Serious illness communication skills (SICS) are essential competencies for clinicians to possess. Unfortunately, SICS teaching is not routinely taught and many clinician teachers (CTs) never received training on how to teach them. We funded two cohorts of CTs to learn an evidence-based approach to SICS teaching to scale a unified approach to such training.
View Article and Find Full Text PDFIn Silico Pharmacol
September 2025
Department of Pharmacoinformatics, National Institute of Pharmaceutical Education and Research (NIPER), Sector 67, S.A.S Nagar, Mohali, Punjab 160062 India.
Unlabelled: The global health crisis caused by SARS-CoV-2 underscores the urgent need for effective antiviral therapeutics. The SARS-CoV-2 main protease (Mpro) is a crucial enzyme in viral replication, making it a prime target for drug development. In this study, we designed and evaluated peptide inhibitors targeting Mpro by introducing systematic mutations in the Nsp10/11 cleavage site peptide (QLMPER).
View Article and Find Full Text PDFCell Res
September 2025
Department of Immunology, Center for Immunotherapy, Institute of Basic Medical Sciences, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China.
The pre-dimerization of endosome-localized RNA sensor Toll-like receptor 3 (TLR3) is required for its innate recognition, yet how TLR3 pre-dimers are formed and precisely primed for innate activation remains unclear. Here, we demonstrate that endosome-localized self RNA Rmrp directly binds to TLR3 and induces TLR3 dimerization in the early endosome but does not interact with endosome-localized TLR7, TLR8, TLR9 or cytoplasmic RNA sensor RIG-I under homeostatic conditions. Cryo-EM structure of Rmrp-TLR3 complex reveals a novel lapped conformation of TLR3 dimer engaged by Rmrp, which is distinct from the activation mechanism by dsRNA and the specific structural feature at the 3'-end of Rmrp is critical for its functional interaction with TLR3.
View Article and Find Full Text PDFAdv Mater
September 2025
School of Chemistry and Biochemistry, School of Materials Science and Engineering, Center for Organic Photonics and Electronics, Georgia Institute of Technology, Atlanta, GA, 30332, USA.
Molecular spin systems that can be chemically tuned, coherently controlled, and readily integrated within devices remain central to the realization of emerging quantum technologies. Organic high-spin materials are prime candidates owing to their similarity in electronic structure to leading solid-state defect-based systems, light element composition, and the potential for entanglement and qubit operations mediated through spin-spin exchange. However, the inherent instability of these species precludes their rational design, development, and application.
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