CircRNA Networks in CAD: Multi-Cellular Mechanisms and Clinical Potential.

Int J Gen Med

Department of Cardiology, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, 650032, People's Republic of China.

Published: June 2025


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Article Abstract

Coronary artery disease (CAD), is a global cardiovascular disease that is characterized by myocardial ischemia and hypoxia caused by coronary artery occlusion. Circular RNAs (CircRNAs) is a particular kind of endogenous non-coding RNA, which can affect the occurrence and development of CAD. Concurrently, several circRNAs display stable persistence in CAD patients, attributable to their exceptional exonuclease resistance, thereby harboring the capacity to evolve into a biomarker for CAD diagnosis and prognosis. This article endeavors to clarify the pivotal role of circRNAs in the intricate pathophysiological processes underlying CAD patients or CAD disease models based on their unique biological characteristics and functionalities, and further discuss their prospects in clinical applications of CAD.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12170827PMC
http://dx.doi.org/10.2147/IJGM.S524189DOI Listing

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