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Article Abstract
A new series of d-glucose-conjugated 2,3-thiazoline-benzo-[]-thiazole hybrid compounds - were synthesized from reaction of the corresponding thioureas - and ethyl bromoacetate in the presence of sodium acetate in chloroform. The evaluations for anti-Alzheimer activity showed that some compounds exhibited remarkable inhibitory activity against AChE and BChE as well as against MAO-A and MAO-B enzymes. The orders of inhibition for each enzyme of these compounds were as follows: > (against AChE), > (against BChE), > > (against MAO-A), and > (against MAO-B). Compound was an inhibitor of interest due to its potent or good activity against the two studied enzymes BChE and MAO-B, respectively. Compounds (against AChE) and (against (BChE) had a competitive type with constants of 16.93 and 17.09 nM, respectively. The most potential compounds , , and were not cytotoxic on 3T3 cells and had high levels of safety.
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| http://dx.doi.org/10.1021/acsmedchemlett.5c00064 | DOI Listing |
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