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Article Abstract
Although posited as an explanation for reproductive endocrine-related mood disorders, differential hormone sensitivity is an elusive concept. In this editorial, we define differential sensitivity, embed it in current understanding of the generation of brain states and discuss its practical utility.
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| http://dx.doi.org/10.1192/bjp.2025.40 | DOI Listing |
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Observing differential spin currents by resonant inelastic X-ray scattering.
Nature
September 2025
National Synchrotron Light Source II, Brookhaven National Laboratory, Upton, NY, USA.
Controlling spin currents, that is, the flow of spin angular momentum, in small magnetic devices, is the principal objective of spin electronics, a main contender for future energy-efficient information technologies. A pure spin current has never been measured directly because the associated electric stray fields and/or shifts in the non-equilibrium spin-dependent distribution functions are too small for conventional experimental detection methods optimized for charge transport. Here we report that resonant inelastic X-ray scattering (RIXS) can bridge this gap by measuring the spin current carried by magnons-the quanta of the spin wave excitations of the magnetic order-in the presence of temperature gradients across a magnetic insulator.
View Article and Find Full Text PDFPML::RARα+ myeloid cells display metabolic alterations that can be targeted to treat resistant/relapse acute promyelocytic leukemias.
Leukemia
September 2025
I.R.C.C.S Santa Lucia Foundation, Via del Fosso di Fiorano, Rome, Italy.
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View Article and Find Full Text PDFModulating the PPARγ pathway upregulates NECTIN4 and enhances chimeric antigen receptor (CAR) T cell therapy in bladder cancer.
Nat Commun
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Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA, USA.
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Department of Orthopedics, Affiliated Yongchuan Hospital of Chongqing Medical University, Chongqing 402160, China. Electronic address:
Bone morphogenetic proteins (BMPs) are effective for treating various orthopedic conditions and are widely used clinically. However, their therapeutic efficacy is limited in osteoporosis patients. Iron overload represents a key risk factor for osteoporosis, inducing ferroptosis and suppressing the osteogenic differentiation of bone marrow stromal cells (BMSCs).
View Article and Find Full Text PDFSmartphone-assisted colorimetric detection of FEN1 and its inhibitors via RCA-magnetic beads-urease cascade amplification.
Biosens Bioelectron
September 2025
College of Pharmacy, Xinjiang Key Laboratory of Biopharmaceuticals and Medical Devices, Xinjiang Medical University, Urumqi, 830017, China; State Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Utilization, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy
Given the pivotal role of Flap endonuclease 1 (FEN1) in tumor pathogenesis and progression, the advancement of its activity and inhibitor assays holds significant importance for cancer research and drug screening. Herein, we proposed a convenient, visual and sensitive colorimetric biosensing platform for FEN1 activity detection by integrating the robust signal amplification power of rolling circle amplification (RCA), the target enrichment capability of magnetic beads (MB), and the high efficiency and visualization of urease-mediated litmus test. Based on the significant color transition with a clear response mechanism, quantitative analysis can be achieved by either spectroscopic or smartphone-based detection.
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