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http://dx.doi.org/10.1016/j.jmig.2025.06.005 | DOI Listing |
Eur J Obstet Gynecol Reprod Biol
August 2025
Department of Gynaecologic Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan, Italy.
Objective: Limited prospective data are available on the outcomes and performance of sentinel node mapping (SNM) in patients with endometrial cancer (EC). This study aimed to describe the surgical outcomes related to laparoscopic staging and the performance of SNM in patients with apparent early-stage EC.
Methods: This is a secondary analysis of a prospective single-arm study focusing on predictors of nodal disease in apparent early-stage EC.
Cureus
July 2025
Department of Obstetrics and Gynecology, Obstetrics and Gynecology Clinic Narodni Front, Belgrade, SRB.
Borderline ovarian tumors (BOTs) are epithelial ovarian neoplasms characterized by cellular proliferation and nuclear atypia without stromal invasion. On the other hand, low-grade appendiceal mucinous neoplasms (LAMNs) have features such as mucin production, a distinct invasion pattern, and low-grade cytological characteristics. Pseudomyxoma peritonei (PMP), an uncommon disorder characterized by mucinous peritoneal dispersion, can be exacerbated by both BOTs and LAMNs.
View Article and Find Full Text PDFImmune checkpoint inhibitors (ICIs) have revolutionized cancer treatment, offering durable responses across multiple malignancies. However, these agents can trigger severe immune-related adverse events (irAEs), including drug-induced autoimmune hemolytic anemia (AIHA), which often necessitates treatment discontinuation. While management guidelines for irAEs are well established, the safety and feasibility of ICI rechallenge after resolution of severe hematologic toxicities remain poorly understood.
View Article and Find Full Text PDFGynecol Oncol Rep
August 2025
Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, University of Pennsylvania, Philadelphia, PA, USA.
Objective: Guillain-Barré syndrome (GBS) is a rare yet potentially life-threatening adverse event of immune checkpoint inhibitors (ICI). It classically presents with ascending symmetric weakness, areflexia, and distal sensory loss. We present a case of pembrolizumab-induced GBS in a patient with advanced endometrial cancer.
View Article and Find Full Text PDFCureus
July 2025
Department of Obstetrics and Gynecology, Faculty of Medicine, Kagoshima University, Kagoshima, JPN.
Objective The objective of this study is to evaluate the surgical safety and oncological outcomes of minimally invasive surgery (MIS) with sentinel lymph node (SN) mapping in older adults (≥70 years) with early-stage endometrial cancer, as part of a prospective cohort study. Methods This study is a subgroup analysis of a prospective cohort comprising 204 patients with International Federation of Gynecology and Obstetrics stage IA endometrial cancer who underwent MIS with SN mapping at a single tertiary center between December 2016 and April 2022. Patients were categorized into two groups based on age: <70 years and ≥70 years.
View Article and Find Full Text PDF