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A 53-year-old woman with hyperinsulinemic hypoglycemia was diagnosed with multiple insulinomas as determined by contrast-enhanced CT. Genetic test confirmed the presence of multiple endocrine neoplasia type 1 (MEN1). 68Ga-exendin-4 PET/CT revealed multiple lesions with intense uptake in the tail and uncinate process of the pancreas, with an additional lesion in the gastric wall on the lesser curvature. These lesions were subsequently confirmed to be insulinomas by histopathologic examination after surgery. This case illustrates the benefits of 68Ga-exendin-4 PET/CT in detecting multiple and ectopic insulinomas in patients with a MEN1 background.
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http://dx.doi.org/10.1097/RLU.0000000000006032 | DOI Listing |
Clin Nucl Med
July 2025
Department of Nuclear Medicine, Fudan University Shanghai Cancer Center.
A 52-year-old man was pathologically diagnosed with a pancreatic neuroendocrine tumor (pNET) and synchronous liver metastasis through debulking surgery 2 years ago. Recently, the patient showed recurrent severe hypoglycemia after receiving multiple treatments. 68Ga-Exendin-4 PET/CT imaging revealed diffuse uptake in the skeleton and other metastatic sites, which 68Ga-DOTANOC PET/CT grossly underestimated.
View Article and Find Full Text PDFClin Nucl Med
June 2025
Department of Nuclear Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College Hospital.
A 53-year-old woman with hyperinsulinemic hypoglycemia was diagnosed with multiple insulinomas as determined by contrast-enhanced CT. Genetic test confirmed the presence of multiple endocrine neoplasia type 1 (MEN1). 68Ga-exendin-4 PET/CT revealed multiple lesions with intense uptake in the tail and uncinate process of the pancreas, with an additional lesion in the gastric wall on the lesser curvature.
View Article and Find Full Text PDFEur J Nucl Med Mol Imaging
May 2025
Department of Nuclear Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, P. R. China.
Purpose: Accurate preoperative localization is imperative for the treatment of insulinomas. Glucagon-like peptide-1 receptor (GLP-1R) imaging has demonstrated remarkable efficacy in localization of insulinomas. The aim of this study was to assess the diagnostic performance of GLP-1R PET/CT with Ga-exendin-4 in localization of insulinoma, and to provide evidence for clinical practice from a real-world study.
View Article and Find Full Text PDFClin Nucl Med
April 2025
Radiation Medicine Centre, Bhabha Atomic Research Centre, Tata Memorial Centre Annexe, Jerbai Wadia Road, Parel.
A 62-year-old woman who experienced a seizure was found to be hypoglycemic. A prolonged fasting test revealed raised critical insulin and C-peptide levels. CECT of the abdomen demonstrated an isodense focus in the tail of the pancreas.
View Article and Find Full Text PDFJCEM Case Rep
November 2024
Department of Endocrinology, PGIMER, Chandigarh 160012, India.