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Article Abstract
Medical Internal Radiation (MIR) Dosimetry formalism has been implemented for a liquid source by establishing CR-39 SSNTD based alpha spectroscopy. The alpha tracks were isolated from the raw tracks by establishing track diameter-brightness correlation. The measured spectrum has been reproduced using cylindrical source model and Geant4 simulations. The equilibrium dose has been estimated by convoluting the obtained equilibrium alpha spectrum with corresponding stopping powers.
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MIR dosimetry using CR-39 based α spectroscopy.
Appl Radiat Isot
November 2025
Nuclear and Radiation Physics Group, Department of Physics, University of Calicut, 673635, India. Electronic address:
Medical Internal Radiation (MIR) Dosimetry formalism has been implemented for a liquid source by establishing CR-39 SSNTD based alpha spectroscopy. The alpha tracks were isolated from the raw tracks by establishing track diameter-brightness correlation. The measured spectrum has been reproduced using cylindrical source model and Geant4 simulations.
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Clinical Trials and Statistics Unit (ICR-CTSU), The Institute of Cancer Research, London, UK; School of Medicine, University of Keele and University Hospitals of North Midlands, Staffordshire, UK.
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January 2025
Radiation Physiology Lab, Singapore Nuclear Research and Safety Initiative, National University of Singapore, Singapore 118415, Singapore.
Our recent study revealed that continuous prenatal low-dose-rate irradiation did not induce cellular changes in the dentate gyrus of the hippocampus in male B6C3F1 mice exposed to gamma rays during prenatal development. However, changes in body weight, body mass index (BMI), locomotor ability, and mRNA and miRNA expressions in the hippocampus and blood were observed. To investigate potential sex differences in the effects of prenatal gamma irradiation, we conducted a parallel study on female B6C3F1 mice.
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Cells
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Radiation Physiology Laboratory, Singapore Nuclear Research and Safety Initiative, National University of Singapore, Singapore.
Our previous study demonstrated that the acute high-dose-rate (3.3 Gy/min) γ-ray irradiation (γ-irradiation) of postnatal day-3 (P3) mice with 5 Gy induced depression and drastic neuropathological changes in the dentate gyrus of the hippocampus of adult mice. The present study investigated the effects of chronic low-dose-rate (1.
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August 2024
JAC Co., Ltd., 1-2-7 Higashiyama, Meguro, Tokyo 153-0043, Japan.
Article Synopsis
- The study investigates the effects of chronic low dose radiation exposure during prenatal and postnatal stages on neurological health, specifically focusing on potential links to neuropsychiatric disorders and changes in the hippocampus in mice.
- Findings show no significant cellular or cognitive impairments in the irradiated mice, but there were noticeable reductions in body weight and exploratory behavior, alongside changes in organ weights without abnormal pathology.
- Molecular analysis revealed specific genes and microRNAs were altered in the hippocampus and blood of irradiated mice, indicating a biological response to radiation exposure despite the absence of major neurological symptoms.