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An elaborately designed multifunctional metasurface based on vanadium oxide (VO) that enables polarization-selective modulation is presented. The metasurface is capable of transitioning between absorption and transmission modes by modulating the two-phase states of VO. When VO acts as a metal state, significant linear dichroism in the absorption mode (LD) is achieved with peak absolute values reaching 0.9 at 7.62 THz and 0.84 at 8.96 THz. Alternatively, when illuminated with circular polarized light, the absorption mode exhibits efficient circular dichroism (CD) over a broad frequency range from 2.96 THz to 6.32 THz, corresponding to a bandwidth of 3.36 THz. Upon transitioning VO into its dielectric state, the metasurface displays multi-band transmission linear dichroism (LD) with a peak absolute value of 0.88. Additionally, it exhibits dual-band transmission circular dichroism (CD) with a maximum absolute value of 0.6. The underlying physical mechanism is elucidated through the application of impedance matching theory and analysis of electromagnetic field distribution. Remarkably, through the strategic arrangement of the original unit cells, their rotational variants, and mirror-image counterparts, we highlight the metasurface's potential in digital imaging display and visualized polarization recognition.
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http://dx.doi.org/10.1364/OE.559294 | DOI Listing |
MAbs
December 2025
Office of Pharmaceutical Quality Research, Office of Pharmaceutical Quality, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, MD, USA.
The analytical comparability of biologic products and their biosimilars, including higher-order structure (HOS) assessment, ensures product quality and is required for regulatory approval. In this study, nuclear magnetic resonance (NMR) spectroscopy was used to evaluate the HOS of Humira (adalimumab) and its biosimilars under normal and photo-stressed conditions. Under normal conditions, 1D and 2D NMR spectra showed strong structural similarity among all products.
View Article and Find Full Text PDFArch Pharm (Weinheim)
September 2025
College of Chemistry, Pingyuan Laboratory (Zhengzhou University), Zhengzhou University, Zhengzhou, China.
The SARS-CoV-2 pandemic has spurred global efforts to develop therapeutic approaches. The main protease (Mpro) of SARS-CoV-2 is crucial for viral replication and a key target for therapeutic development. In this study, 22 thiosemicarbazone derivatives were synthesized.
View Article and Find Full Text PDFJ Sep Sci
September 2025
Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.
Nifurtimox (NFX) is a chiral drug used for the treatment of Chagas Disease. Little attention has been paid to the enantioselective properties of chiral drugs used for neglected tropical diseases, highlighting the need for further studies in this area. In this work, the enantioselective properties of NFX were carefully investigated by HPLC using different chiral stationary phases (CSPs) and chromatographic modes.
View Article and Find Full Text PDFCurr Res Food Sci
August 2025
Department of Molecular Food Chemistry and Food Development, Institute of Food and One Health, Leibniz University Hannover, Am Kleinen Felde 30, 30167, Hannover, Germany.
A- and B-type procyanidins (PCs) are widely known for their health-promoting properties, such as antioxidant activity. The limited availability of reference substances represents a major challenge, resulting in a low number of systematic studies on their health benefits. In our study, the optimised 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical-induced oxidation of the B-types B1 and B2 was carried out yielding the corresponding A-types A1 (1) and A2 (2), which have an additional ether bridge between C2--C7, whereas oxidation of B3 and B4 produced a six-membered spirocyclic ring system including a spiro-carbon atom at C8t (3-5).
View Article and Find Full Text PDFRiceglutelin (RG)-rhamnolipids (Rha)-high-methoxyl pectin (HMP)/medium-methoxy pectin (MMP)/low-methoxy pectin (LMP) were used to attract self-assembled nanoparticles by electrostatic attraction, and the effects of pectin esterification degree and concentration on the characteristics of nanoparticles and the bioavailability of curcumin were evaluated. The minimum particle size and the highest encapsulation efficiency of the nanoparticles were at mass ratios of RG:HMP = 2:1, RG:MMP = 4:1, and RG:LMP = 2:1. The results of Fourier transform infrared spectroscopy and circular dichroism spectroscopy show that hydrogen bonding, hydrophobic interaction, and electrostatic attraction are the main driving forces for the formation of complexes.
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