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We investigate artificial-intelligence-supported in-line holographic imaging with coherent terahertz (THz) radiation. The goal is to reconstruct three-dimensional (3D) scenes from images obtained with detectors that recorded only the power of the radiation and not the phase. This study proposes a novel approach utilizing a physics-informed deep learning (DL) algorithm to reconstruct objects which partially obscure each other. Taking the angular spectrum theory as prior knowledge, we generate a synthetic dataset consisting of a series of diffraction patterns that contain information about the type of objects to be imaged. This dataset, combined with unlabeled data obtained by experiments, are used for the self-training of a physics-informed neural network (NN). During the training process, the NN iteratively predicts images of the objects from the unlabeled dataset and reincorporates these results back into the training set. This recursive strategy includes experimentally recorded images from the studied object class in the NN training, for which the ground truth is unknown. Furthermore, the approach minimizes mutual interference during object reconstruction, demonstrating its effectiveness even in data-scarce situations. The method has been validated with both simulated and experimental data, showcasing its significant potential to advance the field of 3D THz imaging.
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http://dx.doi.org/10.1364/OE.557508 | DOI Listing |
Br J Pharmacol
September 2025
Department of Physiology and Medical Physics, RCSI University of Medicine and Health Sciences, Dublin, Ireland.
Background And Purpose: Neuroinflammation is increasingly recognised to contribute to drug-resistant epilepsy. Activation of ATP-gated P2X7 receptors has emerged as an important upstream mechanism, and increased P2X7 receptor expression is present in the seizure focus in rodent models and patients. Pharmacological antagonists of P2X7 receptors attenuate seizures in rodents, but this has not been explored in human neural networks.
View Article and Find Full Text PDFBehav Res Methods
September 2025
Czech Technical University in Prague, Faculty of Electrical Engineering, Department of Cybernetics, Prague, Czech Republic.
Automatic markerless estimation of infant posture and motion from ordinary videos carries great potential for movement studies "in the wild", facilitating understanding of motor development and massively increasing the chances of early diagnosis of disorders. There has been a rapid development of human pose estimation methods in computer vision, thanks to advances in deep learning and machine learning. However, these methods are trained on datasets that feature adults in different contexts.
View Article and Find Full Text PDFBiol Pharm Bull
September 2025
Computational and Biological Learning Laboratory, University of Cambridge, Cambridge CB21PZ, United Kingdom.
Neuroimaging in rodents holds promise for advancing our understanding of the central nervous system (CNS) mechanisms that underlie chronic pain. Employing two established, but pathophysiologically distinct rodent models of chronic pain, the aim of the present study was to characterize chronic pain-related functional changes with resting-state functional magnetic resonance imaging (fMRI). In Experiment 1, we report findings from Lewis rats 3 weeks after Complete Freund's adjuvant (CFA) injection into the knee joint (n = 16) compared with the controls (n = 14).
View Article and Find Full Text PDFSci Justice
September 2025
Department of Multidisciplinary Radiological Science, The Graduate School of Dongseo University, 47 Jurye-ro, Sasang-gu, Busan 47011, Republic of Korea. Electronic address:
The identification of deceased individuals is essential in forensic investigations, particularly when primary identification methods such as odontology, fingerprint, or DNA analysis are unavailable. In such cases, implanted medical devices may serve as supplementary identifiers for positive identification. This study proposes deep learning-based methods for the automatic detection of metallic implants in scout images acquired from computed tomography (CT).
View Article and Find Full Text PDFBrain Res Bull
September 2025
Department of Psychiatry, Keck School of Medicine, University of Southern California, Los Angeles, CA; Institute for the Developing Mind, Children's Hospital Los Angeles, Los Angeles, CA.
We propose a Biophysically Restrained Analog Integrated Neural Network (BRAINN), an analog electrical network that models the dynamics of brain function. The network interconnects analog electrical circuits that simulate two tightly coupled brain processes: (1) propagation of an action potential, and (2) regional cerebral blood flow in response to the metabolic demands of signal propagation. These two processes are modeled by two branches of an electrical circuit comprising a resistor, a capacitor, and an inductor.
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