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http://dx.doi.org/10.1016/j.surg.2025.109496 | DOI Listing |
Regen Biomater
August 2025
Institute of Stomatology & Oral Maxilla Facial Key Laboratory, First Medical Center of Chinese PLA General Hospital, Beijing 100853, China.
Reconstructing bone defects remains a significant challenge in clinical practice, driving the urgent need for advanced artificial grafts that simultaneously promote vascularization and osteogenesis. Addressing the critical trade-off between achieving high porosity/strength and effective bioactivity at safe ion doses, we incorporated strontium (Sr) into β-tricalcium phosphate (β-TCP) scaffolds with a triply periodic minimal surface (TPMS) structure using digital light processing (DLP)-based three-dimensional (3D) printing. Systematically screening Sr concentrations (0-10 mol%), we identified 10 mol% as optimal, leveraging the synergy between the biomimetic TPMS architecture, providing exceptional mechanical strength (up to 1.
View Article and Find Full Text PDFJ Clin Exp Hepatol
August 2025
Dept of Histopathology, PGIMER, Chandigarh, 160012, India.
Artificial intelligence (AI) is a technique or tool to simulate or emulate human "intelligence." Precision medicine or precision histology refers to the subpopulation-tailored diagnosis, therapeutics, and management of diseases with its sociocultural, behavioral, genomic, transcriptomic, and pharmaco-omic implications. The modern decade experiences a quantum leap in AI-based models in various aspects of daily routines including practice of precision medicine and histology.
View Article and Find Full Text PDFFront Comput Neurosci
August 2025
Department of Biomedical Engineering, Viterbi School of Engineering, University of Southern California, Los Angeles, CA, United States.
Artificial neural networks are limited in the number of patterns that they can store and accurately recall, with capacity constraints arising from factors such as network size, architectural structure, pattern sparsity, and pattern dissimilarity. Exceeding these limits leads to recall errors, eventually leading to catastrophic forgetting, which is a major challenge in continual learning. In this study, we characterize the theoretical maximum memory capacity of single-layer feedforward networks as a function of these parameters.
View Article and Find Full Text PDFJB JS Open Access
September 2025
Department of Orthopaedic Surgery, St. Luke's University Health Network, Bethlehem, Pennsylvania.
Background: The use of artificial intelligence platforms by medical residents as an educational resource is increasing. Within orthopaedic surgery, older Chat Generative Pre-trained Transformer (ChatGPT) models performed worse than resident physicians on practice examinations and rarely answered questions with images correctly. The newer ChatGPT-4o was designed to improve these deficiencies but has not been evaluated.
View Article and Find Full Text PDFFront Vet Sci
August 2025
Pathobiology and Population Science, Royal Veterinary College, Hatfield, United Kingdom.
Diffuse large B-cell lymphoma is the most common type of non-Hodgkin lymphoma (NHL) in humans, accounting for about 30-40% of NHL cases worldwide. Canine diffuse large B-cell lymphoma (cDLBCL) is the most common lymphoma subtype in dogs and demonstrates an aggressive biologic behaviour. For tissue biopsies, current confirmatory diagnostic approaches for enlarged lymph nodes rely on expert histopathological assessment, which is time-consuming and requires specialist expertise.
View Article and Find Full Text PDF