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We demonstrate a compact multilayer GaAs-AlAs structure for passive optical edge detection at multiple wavelengths. Through the inverse design of the layer thicknesses, this structure manipulates spatial frequency components of an incoming wavefront, selectively reflecting high-frequency features while suppressing low-frequency intensity variations. Simulations reveal a reflectance transition from minimal to near-total as a function of numerical aperture, a property leveraged for enhancing edge contrast in optical imaging. For the first time, to our knowledge, we utilize molecular beam epitaxy (MBE) to fabricate edge detection devices, ensuring structural fidelity. Material characterization confirms high-quality interfaces, precise thickness control, and excellent uniformity, validating the suitability of MBE for this application. Experimental angle-resolved reflectance measurements closely align with theoretical predictions, demonstrating the feasibility of this approach for real-time, hardware-based optical image processing. The proposed design automatically works for at least two wavelengths and can be readily extended to operate at multiple wavelengths simultaneously. This work opens new possibilities for employing multilayer interference structures in high-performance optical imaging and real-time signal processing.
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http://dx.doi.org/10.1364/OL.563259 | DOI Listing |
Small
September 2025
Institute of Thin Film Physics and Applications, Shenzhen Key Laboratory of Advanced Thin Films and Applications, Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province, State Key Laboratory of Radio Frequency Heterogeneous Integration, College of Physic
Antimony selenide (SbSe), a narrow-bandgap semiconductor with strong light absorption, exhibits photoresponse up to ≈1050 nm due to its intrinsic 1.15 eV bandgap. To extend detection into the near-infrared (NIR, 700-1350 nm), Bi-alloyed (BiSb)Se is developed via vacuum sputtering and postselenization.
View Article and Find Full Text PDFJ Multidiscip Healthc
September 2025
Department of Public Health, Faculty of Medicine, Universitas Padjadjaran, Sumedang, West Java, Indonesia.
Background: Falls are a major cause of injury and death among the elderly, highlighting the need for effective and real-time detection systems. Embedded Internet of Health Things (IoHT) technologies integrating sensors, microcontrollers, and communication modules offer continuous monitoring and rapid response. However, the research landscape remains fragmented, and no comprehensive bibliometric review has been conducted.
View Article and Find Full Text PDFNat Aging
September 2025
Department of Clinical Molecular Biology, University of Oslo and Akershus University Hospital, Lørenskog, Norway.
Beyond their classical functions as redox cofactors, recent fundamental and clinical research has expanded our understanding of the diverse roles of nicotinamide adenine dinucleotide (NAD) and nicotinamide adenine dinucleotide phosphate (NADP) in signaling pathways, epigenetic regulation and energy homeostasis. Moreover, NAD and NADP influence numerous diseases as well as the processes of aging, and are emerging as targets for clinical intervention. Here, we summarize safety, bioavailability and efficacy data from NAD-related clinical trials, focusing on aging and neurodegenerative diseases.
View Article and Find Full Text PDFProg Mol Biol Transl Sci
September 2025
Division of Sleep Medicine, Louis Stokes Cleveland VA Medical Center, Cleveland, OH, United States; Division of Pulmonary, Critical Care, and Sleep Medicine, University Hospitals Cleveland Medical Center, Cleveland, OH, United States; Department of Medicine, Case Western Reserve University, Clevelan
Obstructive sleep apnea (OSA) is a pervasive disorder characterized by recurrent airway obstructions during sleep. OSA carries serious health risks, such as cardiovascular and cognitive impairments, and imposes a significant economic burden. This chapter provides a comprehensive overview of various biosensors currently employed for OSA detection, including in-lab polysomnography and flow-based home sleep apnea testing.
View Article and Find Full Text PDFCancer Res
September 2025
Morgridge Institute for Research, Madison, Wisconsin, United States.
Patient-derived cancer organoids (PDCOs) are a valuable model to recapitulate human disease in culture with important implications for drug development. However, current methods for rapidly and reproducibly assessing PDCOs are limited. Label-free imaging methods are a promising tool to measure organoid level heterogeneity and rapidly screen drug response in PDCOs.
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