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Cosmetic materials are complex soft compounds, including pigments, emulsifiers, film-formers, and fillers. After evaporation or absorption, they form a residue of inert ingredients called the cosmetic film. This thin layer, deposited on the skin, enhances complexion by smoothing texture, concealing imperfections, and evening skin tone. However, visualizing and characterizing these fragile films on real skin-cosmetic interfaces remains challenging, as they are prone to damage during analysis. Current evaluation methods rely on subjective approaches, such as consumer feedback, color studies, and optical observations, lacking quantitative insights into the relationship between physical properties and sensory experiences. This study introduces X-ray microtomography as a quantitative tool to examine liquid foundation films deposited on an artificial skin substrate. By analyzing parameters such as coverage thickness, profile topography, and skin deformation, this method differentiates cosmetic products at the microscale. Additionally, X-ray microtomography effectively visualizes emulsion droplets in complex formulations, enabling accurate quantification of key parameters like drop size distribution, critical for product texture and stability. These findings demonstrate the potential of X-ray microtomography as a robust, objective approach for studying cosmetic formulations and other soft material-based films, bridging the gap between physical properties and product performance while providing insights for process development and quality improvement.
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http://dx.doi.org/10.1002/smtd.202402202 | DOI Listing |
Front Endocrinol (Lausanne)
September 2025
Shandong University of Chinese Medicine, Jinan, China.
Objective: This study aimed to predict and verify the mechanism of curculigoside in treating osteoporosis using network pharmacology, molecular docking technology, and micro-CT technology.
Methods: Herb databases were searched to identify and screen potential targets of curculigoside. The GeneCards platform was utilized to mine osteoporosis-related targets.
Proc Natl Acad Sci U S A
September 2025
Department of Chemical and Structural Biology, Weizmann Institute of Science, Rehovot 7610001, Israel.
We applied micro-computed tomography, high-resolution cryo-scanning electron microscopy (SEM) combined with cathodoluminescence, and cryo-focused ion beam Milling-SEM to perform three-dimensional imaging of human atherosclerotic tissues with tens of nanometers resolution, under hydrated, near-native conditions with minimal sample processing. The same technology was applied to cultured macrophages exposed to cholesterol crystals, and the observations made on the macrophages were compared to those made on the pathological tissue. We observed that cholesterol crystal digestion and, eventually, cholesterol crystal clearance occurs in the advanced human plaques through cellular processing.
View Article and Find Full Text PDFActa Biochim Pol
September 2025
Department of Biomedical Engineering, UConn Health Center, Farmington, CT, United States.
Human and mouse incisors are both primarily composed of dentin and enamel, which meet at an interface called the dentin-enamel junction (DEJ). However, incisors in the two species have very different growth patterns, structures, and loading requirements. Since the DEJ is responsible for minimizing cracking at this at-risk interface between mechanically dissimilar dentin and enamel, its structure is expected to be significantly different between humans and mice.
View Article and Find Full Text PDFFood Sci Nutr
September 2025
Institute for Agricultural and Forest Systems in the Mediterranean (ISAFoM), Department of Biology, Agriculture and Food Sciences (DiSBA), National Research Council (CNR) Portici Italy.
Accurate olive cultivar identification is critical for ensuring quality control and traceability in the olive oil industry. The International Olive Council (IOC) and the International Union for the Protection of New Varieties of Plants (UPOV) have established standardized protocols for varietal characterization. Over the past two decades, two-dimensional image analysis techniques have been increasingly employed for olive variety identification, utilizing various morphological parameters and machine learning approaches.
View Article and Find Full Text PDFPeerJ
September 2025
Department of Dental Research Cell, Dr. D. Y. Patil Dental College and Hospital, Pune, Maharashtra, India.
Background: Short clinical crowns/abutments (SCC) pose a challenge in achieving adequate retention. Auxiliary retentive features (ARF), such as grooves, are commonly employed to enhance retention. The marginal gap (MG) and internal fit (IF) of restorations are critical factors influencing clinical success.
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