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http://dx.doi.org/10.1001/jamanetworkopen.2025.15002 | DOI Listing |
Mol Nutr Food Res
September 2025
Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
Early-life programming is a major determinant of lifelong metabolic health, yet current preventive strategies focus almost exclusively on maternal factors. Emerging experimental and preclinical data reveal that a father's diet before conception, particularly high-fat intake, also shapes offspring physiology. Here, we synthesize the latest evidence on how such diets remodel the sperm epigenome during two discrete windows of vulnerability: (i) testicular spermatogenesis, via DNA methylation and histone modifications, and (ii) post-testicular epididymal maturation, where small non-coding RNAs are selectively gained.
View Article and Find Full Text PDFBiology (Basel)
August 2025
Department of Biomedical Sciences, Humanitas University, 20090 Pieve Emanuele, Italy.
The microbiota refers to the entire community of microorganisms, including bacteria, viruses, fungi, archaea, and protozoa, that inhabit various anatomical sites and exert complex influences on human health and disease [...
View Article and Find Full Text PDFObes Res Clin Pract
August 2025
Center for Reproductive Medicine, the Third Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan Province, PR China. Electronic address:
Purpose: To investigate the impact of paternal body mass index (BMI) on semen parameters and assisted reproductive outcomes in couples undergoing their first IVF/ICSI-ET cycle.
Materials And Methods: This retrospective study included 7618 couples undergoing IVF/ICSI-ET for maternal tubal/pelvic factors from 2017 to 2023. Paternal BMI was classified according to WHO criteria: normal weight (n = 3433), overweight (n = 3248), and obese (n = 937).
Curr Zool
August 2025
Department of Animal Behavior, College of Bioscience and Biotechnology, Yangzhou University, Yangzhou, Wenhui East Road No.48, Jiangsu 225009, China.
Paternal predation risk can program offspring phenotypes via maternal responses and epigenetic marks of spermatozoa. However, the processes and consequences of this experience in biparental species are unknown. Here, we examined how preconception and postconception paternal cat odor (CO) exposure affects anxiety-like behavior and antipredator response in Brandt's voles ().
View Article and Find Full Text PDFCurr Environ Health Rep
August 2025
Department of Environmental Health, Harvard T.H. Chan School of Public Health, 665 Huntington Avenue, Boston, MA, 02115, USA.
Abstarct: PURPOSE OF REVIEW: It is widely accepted that maternal genes and the in-utero environment can impact offspring's health. While fathers have long been considered mere conduits of genetic information, emerging evidence suggests that the paternal preconception environment can also affect offspring's health. This review delves into the biological mechanisms, beyond DNA inheritance, by which paternal preconception exogenous exposures can shape offspring outcomes, and factors that influence these mechanisms.
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