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Article Abstract
Problem: Endometritis is an inflammatory disorder often associated with microbial imbalance. Common treatments, such as antibiotics, may lead to drug resistance and do not ensure long-term microbial stability.
Method Of Study: This mini review examines vaginal microbiota transplantation (VMT) as a novel approach to the management of endometritis. VMT involves the transfer of healthy microbiota from a donor to restore microbial balance in the recipient.
Results: VMT helps maintain vaginal acidity and inhibit pathogenic bacteria by restoring the dominant Lactobacillus spp. One of its key mechanisms is inhibiting the NF-κB signaling pathway, which leads to a decrease in inflammatory cytokines such as IL-6, IL-1β, and TNF-α. This reduces tissue inflammation and improves healing. VMT is also more biocompatible than antibiotics and can be more effective in combination with other treatments.
Conclusions: VMT is a promising noninvasive approach to the treatment of endometritis, with safety and microbial benefits. However, further studies and standardization of methods are needed to confirm its clinical utility.
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| http://dx.doi.org/10.1111/aji.70104 | DOI Listing |
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