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Background And Aims: The use of fractional flow reserve (FFR) and resting full-cycle ratio (RFR) for assessing intermediate coronary lesions is well-established. However, discordance between these methods occurs in 15%-25% of cases. The objective is to identify clinical and angiographic predictors of discordance between FFR and RFR in a Spanish cohort.
Methods: A prospective cohort study of 94 patients with 107 intermediate coronary lesions was conducted. FFR and RFR were measured, and logistic regression was used to identify predictors of discordance.
Results: Discordance occurred in 15.9% of cases. Independent predictors were active smoking, lesions in the left anterior descending artery, and higher area stenosis percentage.
Conclusion: Smoking, LAD lesions, and stenosis severity predict discordance between FFR and RFR. Further studies are needed to clarify the phenomena that cause such discordance.
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http://dx.doi.org/10.1002/ccd.31682 | DOI Listing |
Clin Res Cardiol
September 2025
Department of (Interventional) Cardiology, Thoraxcenter, Erasmus University Medical Center, Room Rg-628, P.O. Box 2040, 3000 CA, Rotterdam, the Netherlands.
Background: Fractional flow reserve (FFR) for non-culprit lesions (NCLs) in patients with ST-elevation myocardial infarction (STEMI) can be influenced by temporary changes in microvascular resistance. Angiography-derived vessel fractional flow reserve (vFFR) has been tested as a less-invasive alternative.
Aims: The FAST STEMI II study aimed to assess the diagnostic performance of acute-setting vFFR vs.
Am J Prev Cardiol
September 2025
Tsimane Health and Life History Project, San Borja, Bolivia.
Background: Greater deposits of epicardial adipose tissue are associated with atrial fibrillation and coronary disease, but have not been studied in subsistence populations.
Methods: We performed CT imaging to measure coronary artery and thoracic aortic calcium (CAC, TAC), epicardial fat thickness (EFT), liver density, and left atrial (LA) anteroposterior diameter and, using a deep learning-enabled software program, epicardial and thoracic fat volume (EFV, TFV), in two remote Amerindian subsistence populations with minimal coronary artery calcification and virtually no atrial fibrillation. We compared 893 adult Tsimane (mean age 58.
J Am Heart Assoc
September 2025
Division of Preventive Medicine Brigham and Women's Hospital, Harvard Medical School Boston MA USA.
Background: Traditional cardiovascular risk assessment entails investigator-defined exposure levels and individual risk markers in multivariable analysis. We sought to determine whether an alternative unbiased learning analysis might provide further insights into vascular risk.
Methods: We conducted an unsupervised learning (k-means cluster) analysis in the Women's Health Study (N=26 443) using baseline levels of triglycerides, high-sensitivity C-reactive protein, and low-density lipoprotein cholesterol to form novel exposures.
Am J Cardiol
September 2025
Faculty of Medicine, Istanbul University, Istanbul, Turkey; Department of Cardiology, Acibadem International Hospital, Istanbul, Turkey. Electronic address:
Although physiologic evaluation (e.g., fractional flow reserve) of intermediate lesions is well established in other coronary arteries, the left main coronary artery (LMCA) exhibits diagnostic challenges, hindering development of physiology-based decision-making algorithms.
View Article and Find Full Text PDFGynecol Oncol
September 2025
Pathology Unit, Department of Oncology, ASST Sette Laghi, Varese, Italy; Department of Medicine and Technological Innovation, University of Insubria, Varese, Italy. Electronic address:
Background: Vulvar squamous cell carcinoma (VSCC) is subdivided into TP53-mutant (TP53) and HPV-associated (HPV). In recent years, a third group unrelated to TP53 mutation or HPV-association (TP53/HPV) has emerged. However, its prognosis is unclear.
View Article and Find Full Text PDF