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Article Abstract
TolC, a multifunctional outer membrane protein, creates a continuous conduit that extrudes substrates from the bacterial periplasm and the outer leaflet of the inner membrane to the external environment. TolC of species functions as an outer membrane protein of multiple exporters, and is involved in antibiotic efflux, regulation and export of virulence factors, iron homeostasis, and survival under various extreme environments, thereby playing an indispensable role in the pathogenesis of species. This review recapitulates the current knowledge about the functions and regulators of TolC homologous proteins in species.
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