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Ultrasound has an important role in many aspects of central venous catheterization. In the last decade, bedside ultrasound has been regarded as a promising tool also for ensuring an accurate and intraprocedural assessment of the location of the catheter tip, as an alternative or complimentary option to intracavitary electrocardiography. In this regard, 5 years ago the Italian Group of Venous Access Devices (GAVeCeLT) developed detailed protocols for the standardization of this methodology in different populations of patients: neonates (Neo-ECHOTIP), children (ECHOTIP-Ped), and adults (ECHOTIP). In the lapse of time since the publication of these protocols, recent clinical studies have brought novel information and new evidence, so that some recommendations included in the original ECHOTIP protocol for adults today may seem incomplete or inappropriate. For this reason, GAVeCeLT has developed an updated version of the protocol, nick-named ECHOTIP-2, which includes new recommendations in regards of some technical aspects of the procedure of bubble test and of the application of the method to femorally inserted central catheters.
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http://dx.doi.org/10.1177/11297298251347084 | DOI Listing |
Infect Drug Resist
September 2025
Department of Intensive Care Unit, The Second Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang, People's Republic of China.
Objective: To investigate the clinical efficacy and safety of intravenous omadacycline compared to intravenous tigecycline in patients with severe pneumonia caused by carbapenem-resistant gram-negative bacilli (CRGNB), and to explore the factors influencing 28-day all-cause mortality.
Methods: Our retrospective analysis was conducted on adult patients with CRGNB-associated severe pneumonia who received intravenous omadacycline or tigecycline for at least 72 hours in the intensive care unit (ICU) between April 1, 2023, and March 31, 2025. The primary outcome was 28-day all-cause mortality, while secondary endpoints included clinical efficacy and microbiological clearance rates.
Curr Med Imaging
May 2025
Department of Radiology, Tianjin First Central Hospital, School of Medicine, Nankai University, Tianjin, China.
Background: Predicting the recurrence risk of NMIBC after TURBT is crucial for individualized clinical treatment.
Objective: The objective of this study is to evaluate the ability of radiomic feature analysis of intratumoral and peritumoral regions based on computed tomography (CT) imaging to predict recurrence in non-muscle-invasive bladder cancer (NMIBC) patients who underwent transurethral resection of bladder tumor (TURBT).
Methods: A total of 233 patients with NMIBC who underwent TURBT were retrospectively analyzed.
Arterial thrombosis is a multifaceted process characterized by platelet aggregation and fibrin deposition, leading to the occlusion of blood vessels. It plays a central role in cardiovascular conditions such as myocardial infarction and ischemic stroke. Gaining insight into the mechanisms underlying arterial thrombosis is essential for developing effective treatments aimed at preventing thrombotic events and reducing associated health burdens.
View Article and Find Full Text PDFKhirurgiia (Mosk)
September 2025
Mandryka Central Military Clinical Hospital, Moscow, Russia.
Widespread fragmentation shells in combat operations with frequent multiple damage to organs and systems force to use all available diagnostic methods for treating severe injuries including lesion of great vessels of extremities. One of the consequences of these lesions is arteriovenous fistula (AVF). The last one may be asymptomatic at first.
View Article and Find Full Text PDFN Engl J Med
September 2025
Division of Medical Oncology, Yonsei Cancer Center, Yonsei University College of Medicine, Seoul, South Korea.
Background: Previous results from this phase 3 trial showed that progression-free survival among participants with previously untreated (epidermal growth factor receptor)-mutated advanced non-small-cell lung cancer (NSCLC) was significantly improved with amivantamab-lazertinib as compared with osimertinib. Results of the protocol-specified final overall survival analysis in this trial have not been reported.
Methods: We randomly assigned, in a 2:2:1 ratio, participants with previously untreated -mutated (exon 19 deletion or L858R substitution), locally advanced or metastatic NSCLC to receive amivantamab-lazertinib, osimertinib, or lazertinib.