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Objectives: To investigate the effect of overnight orthokeratology (OOK) on ocular surface and blinking patterns in children and adolescents.
Methods: A prospective cohort study was conducted including 27 eyes of 27 children from Beijing Tongren Hospital who received OOK correction and 31 eyes of 31 spectacle wearing children. Tests were performed before and at 3 and 6 months after OOK wear. Ocular surface assessment included tear meniscus height, noninvasive tear breakup time, lipid layer thickness, number of incomplete blinks, number of total blinks, and fluorescein tear breakup time.
Results: Before treatment, there were no statistically significant differences in various indicators between the two groups. After wearing OOK for 3 months and 6 months, there were no significant differences between the tear meniscus height, noninvasive tear breakup time, lipid layer thickness, number of incomplete and total blinks, fluorescein tear breakup time groups, and upper and lower lid meibomian gland atrophy rate ( P >0.05). However, the corneal fluorescein staining scores in the OOK group were significantly higher than those in the spectacle group ( P <0.001).
Conclusions: Short-term use of OOK in children and adolescents has a relatively minor impact on ocular surfaces and is considered relatively safe to use. However, it significantly increases corneal fluorescein staining scores, which may suggest the presence of corneal epithelial damage.
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http://dx.doi.org/10.1097/ICL.0000000000001197 | DOI Listing |
Transl Vis Sci Technol
September 2025
School of Optometry and Vision Science, University of New South Wales, Sydney, NSW, Australia.
Purpose: To investigate the short-term impact of exposure to smoke from vegetation burns on ocular surface symptoms and signs.
Methods: Woody bushfuels were burnt in an enclosed room (Flammability Laboratory, University of Tasmania, Australia) to generate particulate matter and monitored in real time (Dust Trak II). Eighteen participants (aged 20-63 years, 8 males and 10 females) fitted with respirators were seated 1.
Arch Soc Esp Oftalmol (Engl Ed)
September 2025
Grupo de investigación GIESVI, Facultad de Optometría, Universidad Santo Tomás, Bucaramanga, Colombia.
Objective: To determine the state of ocular surface and tear film in college students who are users of inhalants, mainly vapers.
Methods: We conducted a descriptive, observational, and cross-sectional study with 62 participants whose sociodemographic characteristics, ocular surface status, tear film and variables related to vaping were evaluated. Individuals with a higher (5-7 times per week of consumption) and lower frequency of vaping (1-4 times per week of consumption) were evaluated.
Exp Eye Res
September 2025
Department of Ophthalmology and Visual Sciences, Escola Paulista de Medicina, Universidade Federal de São Paulo, Brazil.
The ocular surface microbiome plays a crucial role in maintaining immune homeostasis, and its disruption may contribute to mucosal inflammation and autoimmunity. This pilot exploratory study investigated and compared the ocular surface bacterial microbiome in patients with Stevens-Johnson syndrome (SJS), Sjögren's disease (SjD), and healthy controls using next-generation sequencing (NGS) and correlated these findings with dry eye parameters. Conjunctival swabs were collected from sixteen individuals: ten with SJS, three with SjD, and three healthy controls.
View Article and Find Full Text PDFWorld J Methodol
December 2025
Department of Ophthalmology, University Hospital of Udine, Udine 33100, Italy.
Background: Dry eye disease (DED) represents a multifactorial condition characterized by ocular discomfort and visual disturbances. The management of DED relies heavily on accurate diagnosis to tailor effective treatments. Diagnostic approaches encompass both subjective and objective assessments.
View Article and Find Full Text PDFMedicine (Baltimore)
August 2025
College of Traditional Chinese Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou, China.
This narrative review systematically analyzes outcome indicators in clinical research on traditional Chinese medicine (TCM) interventions for dry eye, aiming to analyze current methodological patterns and establish foundations for core outcome set development. Through comprehensive searches across Chinese (China National Knowledge Infrastructure, VIP Database for Chinese Technical Periodicals, Wanfang) and English databases (PubMed, Cochrane Library, Embase), 863 clinical studies were identified and analyzed for outcome indicator usage. Forty-six distinct outcome indicators were documented, cumulatively appearing 3885 times across 6 categories.
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